When is recanalization too late to salvage brain tissue ?
When is the use of thrombolytic agents, which increase the risk of brain hemorrhage, too dangerous ?
Other trials which randomized patients with six hours of symptom onset showed no benefit from thrombolytic therapy.
The most feared complication of rt-PA administration is symptomatic brain hemorrhage, usually into the infarcted area.
Whether to proceed to thrombolysis in an individual patient should be based upon a discussion about the risks and benefits with the patient and family.
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