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Medications and their Potential to Cause Increase 'Drowsiness'(Somnolence)


This section presents medications that are known to potentially lead to 'Drowsiness' as a side effect. It's important to note that mild side effects are quite common with medications.
Please be aware that the drugs listed here are individual medications and may be part of a broader combination therapy. This information is meant to be a helpful resource but should not replace professional medical advice. If you're concerned about 'Drowsiness', it's best to consult a healthcare professional.
In addition to 'Drowsiness', other symptoms or signs might better match your side effect. We have listed these below for your convenience. If you find a symptom that more closely resembles your experience, you can use it to identify potential medications that might be the cause.

Drugs with the Side Effect - Drowsiness

Acetaminophen and Codeine


Most other Common Side Effects: lightheadedness, dizziness, slow heartbeat, sedation, shortness of breath, unusual thoughts or behavior, nausea, vomiting, flushing, vision changes, easy bruising or bleeding, stomach pain, loss of appetite, constipation, itching, decrease in platelets in blood, dark urine, clay-colored stools and difficulty in urinating

Acetaminophen, Butalbital and Caffeine


Most other Common Side Effects: lightheadedness, tremor, dizziness, sedation, shortness of breath, nausea, vomiting, and abdominal pain

Agalsidase


Most other Common Side Effects: Chills, fever, feeling hot or cold, difficulty in breathing, nausea, swelling of the face, mouth, and throat, flushing, headache, vomiting, tingling, fatigue, itching, pain in extremity, high blood pressure, chest pain, throat tightness, abdominal pain, dizziness, fast heart rate, nasal congestion, diarrhea, muscle pain, back pain, pallor, slow heart rate, hives, low blood pressure, face swelling, rash

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Almotriptan


Most other Common Side Effects: Nausea, headache, tingling and dry mouth

Apomorphine


Most other Common Side Effects: Yawning, involuntary movements, nausea, vomiting, bruising, redness at the injection site region, dizziness, runny nose, hallucinations, swelling, chest pain, increased sweating, flushing and pallor

Asenapine


Most other Common Side Effects: Brain disorder, movement disorder

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Aspirin and Oxycodone


Most other Common Side Effects: Brain disorder, movement disorder

Azelastine


Most other Common Side Effects: Bitter taste, headache, nasal burning, inflammation of pharynx/nose, dry mouth, sneezing, nausea, fatigue, dizziness, nosebleed and increased weight

Baclofen


Most other Common Side Effects:

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Bendamustine Hydrochloride


Most other Common Side Effects: Fever, nausea and vomiting, weakness, fatigue, uneasiness, dry mouth, cough, constipation, headache and mouth ulcer

Biperiden


Most other Common Side Effects: dizziness, headache, loss of appetite, blurred vision, agitation, postural hypotension, stomach upset, vision changes, sleeplessness, trembling of the hands and dry mouth

Brompheniramine


Most other Common Side Effects: confusion, dizziness, dryness of mouth, nose, and throat, nausea, vomiting, abdominal cramps, headache and chest congestion

Butabarbital


Most other Common Side Effects:

Captopril


Most other Common Side Effects:

Carbamazepine


Most other Common Side Effects:

Carbidopa-Levodopa


Most other Common Side Effects:

Cetirizine


Most other Common Side Effects: Headache, inflammation of pharynx, abdominal pain, cough, diarrhea, nosebleed, asthma, nausea and vomiting

Chlordiazepoxide


Most other Common Side Effects: dizziness, tiredness, weakness, dry mouth, diarrhea, stomach upset and changes in appetite

Chlorpheniramine


Most other Common Side Effects:

Chlorpheniramine- Hydrocodone- Pseudoephedrine


Most other Common Side Effects: Sedation, mental clouding, lethargy, impairment of mental and physical performance, anxiety, fear, dizziness, psychic dependence, mood changes, nervousness, sleeplessness, visual disturbances, confusion, headache, emotion, involuntary repetitive movements of face, lightheadedness, agitation, restlessness, irritability, tremor

Chlorpromazine


Most other Common Side Effects: Jaundice, involuntary muscle movements, reduced white blood cell counts, raised alkaline phosphatase

Chlorpropamide


Most other Common Side Effects: Jaundice, involuntary muscle movements, reduced white blood cell counts, raised alkaline phosphatase

Cinitapride


Most other Common Side Effects:

Clonidine


Most other Common Side Effects: Dry mouth, fatigue, headache, lethargy, sedation, sleeplessness, dizziness, impotence/sexual dysfunction, dry throat, constipation, tingling, nausea and vomiting

Cyclobenzaprine


Most other Common Side Effects: headache, dizziness, blurred vision, nausea, abnormal taste, palpitations, tremor, dry throat, pimples, attention disturbances, sleeplessness, fatigue, constipation and indigestion

Desvenlafaxine


Most other Common Side Effects: Nausea, dizziness, sleeplessness, excessive sweating, constipation, decreased appetite, anxiety and specific male sexual function disorders

Dexmethylphenidate Hcl


Most other Common Side Effects: Nausea, dizziness, sleeplessness, excessive sweating, constipation, decreased appetite, anxiety and specific male sexual function disorders

Diazepam


Most other Common Side Effects: fatigue and incoordination

Dichlorphenamide


Most other Common Side Effects: Loss of appetite, nausea, vomiting

Diltiazem


Most other Common Side Effects: Loss of appetite, nausea, vomiting

Disulfiram


Most other Common Side Effects: Loss of appetite, nausea, vomiting

Divalproex


Most other Common Side Effects: Nausea, vomiting, dizziness, weakness, abdominal pain, indigestion and rash

Doxylamine


Most other Common Side Effects: Dry mouth, nose and throat, nausea, difficulty in urinating

Enflurane


Most other Common Side Effects: High body temperature, hallucinations, abnormal heart rhythm, fainting or lightheadedness

Etizolam


Most other Common Side Effects: sedation, muscle weakness and incoordination

Felbamate


Most other Common Side Effects: Loss of appetite, vomiting, nausea, dizziness

Fentanyl Sublingual Tablets


Most other Common Side Effects: Nausea, constipation

Flunarizine


Most other Common Side Effects:

Fluoxetine and Olanzapine


Most other Common Side Effects: Disturbance in attention, dry mouth, fatigue, excessive sleepiness, increased appetite, swelling in the extremities, tremor, blurred vision , and increased weight

Flurazepam


Most other Common Side Effects: Dizziness, light-headedness, staggering, in-coordination and falling

Fluvoxamine


Most other Common Side Effects: Nausea, sleeplessness, headache, weakness, vomiting, nervousness, agitation and dizziness

Fomepizole


Most other Common Side Effects: Headache, nausea, dizziness

Furosemide and Spironolactone


Most other Common Side Effects: Fluid and electrolyte imbalance, dehydration, nausea, diarrhea, blurred vision, headache, dizziness, low blood pressure, liver dysfunction, high blood sugar

Gabapentin Enacarbil


Most other Common Side Effects: sedation and dizziness

Guanabenz


Most other Common Side Effects: Dry mouth, dizziness, weakness, headache, decreased sexual ability, stomach upset

Ketorolac


Most other Common Side Effects: Rash, ringing in the ears, headache, dizziness, abdominal pain, nausea, diarrhea, constipation, heartburn and fluid retention

Lamotrigine


Most other Common Side Effects: Adult: Rash, dizziness, headache, lack of coordination, nausea, vomiting, blurred vision, and nose inflammation

Lithium


Most other Common Side Effects: Diarrhea, vomiting, muscular weakness and lack of coordination

Loratadine


Most other Common Side Effects: Fatigue, giddiness, dizziness, dry mouth, headache

Lurasidone


Most other Common Side Effects: unpleasant sensations, nausea, parkinsonism and agitation

Meningococcal C,Y and Haemophilus B Tetanus Toxoid


Most other Common Side Effects: Irritability, loss of appetite, and fever

Mephenesin


Most other Common Side Effects: Lassitude, weakness, loss of appetite, nausea and vomiting, hypersensitivity reactions

Mephobarbital


Most other Common Side Effects:

Meprobamate and Aspirin


Most other Common Side Effects: heartburn or indigestion, nausea with or without vomiting and stomach pain (mild)

Methimazole


Most other Common Side Effects: heartburn or indigestion, nausea with or without vomiting and stomach pain (mild)

Methylphenidate


Most other Common Side Effects: Nervousness, difficulty in sleeping, skin rash, loss of appetite, dizziness, palpitations, fever, sore throat, unusual bleeding or bruising

Methyltestosterone


Most other Common Side Effects: Nervousness, difficulty in sleeping, skin rash, loss of appetite, dizziness, palpitations, fever, sore throat, unusual bleeding or bruising

Morphine Sulfate and Naltrexone Hydrochloride


Most other Common Side Effects: dizziness, constipation and nausea

Nabilone


Most other Common Side Effects: Dizziness, dry mouth, elevated mood, anxiety, lightheadedness, headache, trouble sleeping, memory problems, confusion and depression

Nefazodone


Most other Common Side Effects: dry mouth, dizziness, constipation, weakness, lightheadedness, blurred vision, confusion and abnormal vision

Nefopam


Most other Common Side Effects: lightheadedness, dry mouth, pink colored urine, nervousness, difficulty in urination, nausea, fainting, tremor and confusion

Nicorandil


Most other Common Side Effects: Headache, dizziness, nausea, vomiting, flushing, weakness and rectal bleeding

Orphenadrine


Most other Common Side Effects: Agitation, dizziness, emotion, hallucinations, headache and mental confusion

Oxcarbazepine


Most other Common Side Effects: Dizziness, double vision, running nose, fatigue, nausea, vomiting, ataxia, abnormal vision, sore throat, abdominal pain, tremor, indigestion, abnormal gait

Oxymorphone


Most other Common Side Effects: Nausea, constipation, dizziness, vomiting, itching, headache and increased sweat

Paliperidone Palmitrate


Most other Common Side Effects: Extra pyramidal symptoms, fast heart rate, inner restlessness, indigestion, constipation, weight increased, and inflammation of nasopharynx

Paroxetine


Most other Common Side Effects: Weakness, sweating, nausea, decreased appetite, dizziness, sleeplessness, tremor, nervousness, ejaculatory disturbance, and other male genital disorders

Penicillamine


Most other Common Side Effects: Weakness, sweating, nausea, decreased appetite, dizziness, sleeplessness, tremor, nervousness, ejaculatory disturbance, and other male genital disorders

Pentobarbital


Most other Common Side Effects:

Perampanel


Most other Common Side Effects: Dizziness, headache, fatigue, irritability

Pethidine


Most other Common Side Effects: Nausea, vomiting, constipation, dizziness, dry mouth and sweating

Phenobarbital


Most other Common Side Effects: raised alkaline phosphatase

Piribedil


Most other Common Side Effects: Nausea, vomiting, dizziness, confusion

Plicamycin


Most other Common Side Effects: Loss of appetite, nausea, vomiting, diarrhea, mouth ulcer, fever, weakness, lethargy, uneasiness, headache, depression, vein inflammation, facial flushing, and skin rash

Pralidoxime


Most other Common Side Effects: Blurred vision, double vision, impaired accommodation, dizziness, headache, nausea, muscle weakness, and fast heart rate

Pramipexole


Most other Common Side Effects: Nausea, dizziness, somnolence, insomnia, constipation, weakness and hallucinations

Prazosin


Most other Common Side Effects: Dizziness, headache, lack of energy, weakness, palpitations and nausea

Prochlorperazine


Most other Common Side Effects: dizziness, absence of menstrual periods, blurred vision, skin reactions and Neuroleptic Malignant Syndrome (NMS)

Raxibacumab


Most other Common Side Effects: Rash, pain in extremity

Ropinirole


Most other Common Side Effects: Involuntary movements, nausea, dizziness, hallucinations, abdominal pain/discomfort and low blood pressure

Rufinamide


Most other Common Side Effects:

Sodium Oxybate


Most other Common Side Effects: Headache, nausea, dizziness, throat pain, vomiting, and urinary incontinence

Terazosin


Most other Common Side Effects: headache, weakness, palpitations, stuffy nose, blurred vision and decreased sexual ability

Thalidomide


Most other Common Side Effects: dizziness, constipation, confusion, difficulty in breathing and rash

Thiopental


Most other Common Side Effects: Respiratory depression, heart attack, irregular heart rate, sneezing, coughing, asthma and shivering

Tiagabine


Most other Common Side Effects: Dizziness, lightheadedness, weakness, nausea, nervousness, tremors, abdominal pain, abnormal or difficulty with thinking or concentration or attention

Tolcapone


Most other Common Side Effects: Movement disorder, nausea, sleep disorder, involuntary movements, excessive dreaming, loss of appetite, muscular cramps, orthostatic complaints, diarrhea, confusion, dizziness, headache, hallucinations, vomiting, constipation, fatigue, upper respiratory tract infection, falling, increased sweating, urinary tract infection, dry mouth, abdominal pain and urine discoloration

Tramadol


Most other Common Side Effects: Dizziness/vertigo, nausea, constipation, headache, vomiting, itching, CNS stimulation, weakness, sweating, indigestion, dry mouth and diarrhea

Triazolam


Most other Common Side Effects: Weakness, tiredness, dizziness, clumsiness, unsteadiness, "hangover" effect, headache, increased dream frequency, loss of memory, nausea and vomiting

Trifluoperazine


Most other Common Side Effects: dizziness, skin reactions, rash, dry mouth, sleeplessness, absence of menstrual periods, fatigue, muscular weakness, loss of appetite, spontaneous secretion of milk, blurred vision and neuromuscular (extrapyramidal) reactions

Vigabatrin


Most other Common Side Effects: Headache, fatigue, dizziness, seizures, increased weight, upper respiratory tract infection, visual defects, depression, tremor, night blindness, nausea, diarrhea, memory loss, sleeplessness, irritability, abnormal coordination, blurred vision, double vision, vomiting, influenza, fever and rash

Ziprasidone


Most other Common Side Effects: Nausea, vomiting, runny nose, weakness

Zolmitriptan


Most other Common Side Effects: Pain or tightness in the chest or throat, tingling sensations, flushing, weakness, dizziness, abdominal discomfort and sweating

Zonisamide


Most other Common Side Effects: loss of appetite, dizziness, unsteadiness, agitation/irritability, memory loss and poor concentration

Find drugs that can cause other symptoms like 'Drowsiness'

References

  1. https://www.fda.gov/drugs/information-consumers-and-patients-drugs/finding-and-learning-about-side-effects-adverse-reactions
  2. https://nctr-crs.fda.gov/fdalabel/ui/search
  3. https://dailymed.nlm.nih.gov/dailymed/
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