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Side effect(s) of Sulfasalazine


Review the side-effects of Sulfasalazine as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

   Most Common
- Nausea, indigestion, rash, headache, abdominal pain, vomiting, fever, dizziness, mouth ulcer, itching, abnormal liver function tests, decrease in white blood cells and decrease in platelets.

   Blood
- Anemia and bruising.

   Hypersensitivity
- Redness of the skin, skin death, shock, hives, hair loss, joint pain, lung inflammation and difficulty in breathing.

   Gastrointestinal
- Liver failure, bloody diarrhea, diarrhea, abdominal pain and intestinal inflammation.

   Central Nervous System
- Convulsions, sleeplessness, unsteadiness, paralysis, mental depression, unsteadiness, hearing loss, incoordination, hallucinations, ringing in the ear and drowsiness.

   Genitourinary
- Absence of urination, kidney inflammation, urinary tract infections, blood in urine and protein in urine.

Other Precautions :

Avoid excess dosage. Sulfasalazine can cause reduced sperm count in some men which is reversible in 2-3 months after stopping treatment. It also changes the color of the urine and tears making it slightly yellow-orange. Soft Contact lenses may get stained, recommended to use glasses.

Drug Name : Sulfasalazine

Sulfasalazine(Azulfidine) generic is a salicylate, prescribed for ulcerative colitis. It decreases inflammation.


Trade Names for Sulfasalazine

India :


International :


Azulfidine, Azulfidine EN-tabs
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