Side effect(s) of Nusinersen

Last Updated on Jul 25, 2023

Review the side-effects of Nusinersen as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

  Respiratory System: Respiratory tract infections, difficulty in breathing

  Blood: Reduced platelet count, problems with blood clotting

  Kidneys: Possible kidney damage

  ENT: Ear infection

  Gastrointestinal System: Constipation

  Central Nervous System: Scoliosis (sideways curving of the spine).

Other Precautions :

• Nusinersen injection may increase the risk of bleeding. Therefore it is essential to perform blood tests for platelet count and clotting at the baseline before each dose of the drug to monitor for early signs.
• Do not administer the injection if there is a presence of any particular matter or discoloration.
• Check the urine for protein for any indication of renal toxicity

Drug Name : Nusinersen

Nusinersen generic Nusinersen is a survival motor neuron (SMN-2) directed antisense oligonucleotide which is prescribed for the treatment of spinal muscular atrophy (SMA) in children and adults. Spinal muscular atrophy is a genetic disease which affects the nervous system and causes weakness of muscles under voluntary control. Oligonucleotides are small strands of DNA or RNA that can bind to specific molecules of RNA. Nusinersen increases the production of SMN protein, which is deficient in these patients. It lowers triglycerides and very-low-density lipoprotein (VLDL) level.

Last Updated on Jul 25, 2023