Side effect(s) of Evolocumab

Last Updated on Jan 31, 2023

Review the side-effects of Evolocumab as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

  Gastrointestinal: Diarrhea, nausea, abdominal pain and gastroenteritis

  Cardiovascular system: Raised blood pressure, increased or decreased heartbeat

  Central Nervous System: Headache and dizziness

  Respiratory: Nasopharyngitis, sinusitis, influenza, cough, upper respiratory tract infections, and difficulty in breathing

  Skin: Itching, rashes, injection site reactions such as erythema, pain and bruising

  Others: Fever, swelling of the face or lips or eyes, weakness, backpain, myalgia or musculoskeletal pain, urinary tract infection, and dysuria (pain or burning sensation during urination)

Other Precautions :

• Treatment with evolocumab should not be stopped suddenly because the levels of LDL cholesterol may increase.
• Evolocumab is only a part of the treatment which requires frequent lipid profile testing and necessary dose adjustments as per the advice of the physician.

Drug Name : Evolocumab

Evolocumab generic Evolocumab is prescribed as an adjunct to a low-fat diet and other cholesterol medications in treating patients with high low-density lipoprotein (LDL) cholesterol, total cholesterol, heterozygous familial hypercholesterolemia (HeFH) or homozygous familial hypercholesterolemia (HoFH); HeFH and HoFH are inherited conditions in which cholesterol is not removed from the body. Evolocumab is also recommended for patients with heart disease caused by atherosclerosis (accumulation of cholesterol along the arterial walls). Atherosclerosis leads to decreased blood flow and reduced oxygen supply to the heart, brain and other parts of the body. Evolocumab works by inhibiting a protein called proprotein convertase subtilisin kexin type 9 (PCSK9) that binds to LDL receptors on liver cells. With fewer PCSK9 proteins available, LDL receptors are free to remove LDL from the blood decreasing the chances of atherosclerosis. It works by dulling the pain perception center in the brain.

Last Updated on Jan 31, 2023