Side effect(s) of Cerliponase Alfa

Last Updated on Jul 05, 2023

Review the side-effects of Cerliponase Alfa as documented in medical literature. The term "side effects" refers to unintended effects that can occur as a result of taking the medication. In majority of the instances these side-effects are mild and easily tolerable, however sometimes they can be more severe and can be detrimental.

If the side effects are not tolerable adjusting the dosage or switching to a different medication can help to manage or overcome side effects. If you have any doubts or questions, we recommend seeking advice from your doctor or pharmacist.

  General: Allergic reaction, fever, vomiting, hematoma (blood clot), infection

  Central Nervous System: Headache, irritability, feeling jittery, decrease or increase of cerebrospinal fluid protein, increased WBC count in the cerebrospinal fluid, seizures

  Cardio vascular system: ECG abnormalities including bradycardia (reduced heart rate), low blood pressure

Other Precautions :

The intraventricular access device should considered for replacement after around 105 perforations or roughly after 4.3 years of regular use.

Drug Name : Cerliponase Alfa

Cerliponase Alfa generic Cerliponase alfa is recombinant human tripeptidyl peptidase-1 enzyme (TPP1) which is required for normal brain development. It is used to slow down the loss of walking ability in symptomatic pediatric patients from the age group of 3 years and above who suffer from late infantile neuronal ceroid lipofuscinosis type 2 (CLN2), a form of Batten disease. These patients lack the tripeptidyl peptidase-1 enzyme (TPP1) in their central nervous system (CNS). Cerliponase alfa is infused directly into the patient’s brain bypassing the blood brain barrier through a device called an intraventricular device. It works by decreasing the amount of certain hormones in the body.