It comes as a solution for injection as directed by your health care provider.
Streptomycin therapy should be terminated when toxic symptoms, organism resistant have appeared or when full treatment effect has been obtained. The total treatment period of tuberculosis is minimum one year.
Tularemia: One to two grams daily in divided doses for 7 to 14 days until the patient is feverless for 5 to 7 days.
Plague: Two grams daily in two divided doses should be administered intramuscularly. A minimum of 10 days of therapy is recommended.
Bacterial Endocarditis
a. Streptococcal endocarditis: In penicillin-sensitive alpha and non-hemolytic streptococcal endocarditis (penicillin MIC<0.1 mcg/mL), streptomycin may be used for 2-week treatment concomitantly with penicillin. The streptomycin regimen is 1 g twice daily for the first week, and 500 mg twice daily for the second week. If the patient is over 60 years of age, the dosage should be 500 mg twice daily for the entire 2-week period.
b. Enterococcal endocarditis: Streptomycin in doses of 1 g twice daily for 2 weeks and 500 mg twice daily for an additional 4 weeks is given in combination with penicillin. Ototoxicity may require termination of the streptomycin prior to completion of the 6-week course of treatment.
Adults: For moderate to severe infections, the recommended dose is 1 to 2 grams in divided doses every six to twelve hours. Doses should not exceed 2 grams per day.
Children: 20 to 40 mg/kg/day (8 to 20 mg/lb/day) in divided doses every 6 to 12 hours.
Dosage & When it is to be taken
Tuberculosis: This medication is usually administered daily as a single intra muscular injection. A total dose of not more than 120 g over the course of therapy should be given unless there are no other therapeutic options. In patients older than 60 years of age the drug should be used at a reduced dosage due to the risk of increased toxicity.Streptomycin therapy should be terminated when toxic symptoms, organism resistant have appeared or when full treatment effect has been obtained. The total treatment period of tuberculosis is minimum one year.
Tularemia: One to two grams daily in divided doses for 7 to 14 days until the patient is feverless for 5 to 7 days.
Plague: Two grams daily in two divided doses should be administered intramuscularly. A minimum of 10 days of therapy is recommended.
Bacterial Endocarditis
a. Streptococcal endocarditis: In penicillin-sensitive alpha and non-hemolytic streptococcal endocarditis (penicillin MIC<0.1 mcg/mL), streptomycin may be used for 2-week treatment concomitantly with penicillin. The streptomycin regimen is 1 g twice daily for the first week, and 500 mg twice daily for the second week. If the patient is over 60 years of age, the dosage should be 500 mg twice daily for the entire 2-week period.
b. Enterococcal endocarditis: Streptomycin in doses of 1 g twice daily for 2 weeks and 500 mg twice daily for an additional 4 weeks is given in combination with penicillin. Ototoxicity may require termination of the streptomycin prior to completion of the 6-week course of treatment.
Adults: For moderate to severe infections, the recommended dose is 1 to 2 grams in divided doses every six to twelve hours. Doses should not exceed 2 grams per day.
Children: 20 to 40 mg/kg/day (8 to 20 mg/lb/day) in divided doses every 6 to 12 hours.
