• Plecanatide comes as a tablet to be taken by mouth. The tablet should be swallowed as a whole with sufficient quantity of water.
• For the patients who have swallowing difficulties, the tablets can be taken by crushing and mixing with water or applesauce.
• It can also be crushed as a powder and mixed with water for administering through a nasogastric or gastric feeding tube.
For oral administration with water:
• Place the tablet in a clean cup and add about 30ml of normal potable or room temperature water. Gently swirl for nearly 10 seconds and should be taken immediately.
• If any residue or leftover found in the cup add another 30 ml of water, swirl and take immediately.
For oral administration with applesauce:
• Powder the tablet in a clean cup and mix with 1 teaspoonful of applesauce and consume all the mixture immediately.
For administration with water through a nasogastric or gastric feeding tube:
• Place the tablet in a clean cup and add about 30ml of normal potable water at room temperature. Gently swirl for nearly 15 seconds.
• Flush the nasogastric tube or gastric feeding tube with 30ml of room temperature water and draw the plecanatide mixture by using the syringe and administer immediately.
• If any residue is left in the cup add 30ml of water to the cup, swirl for at least 15 seconds and draw the plecanatide mixture by using the same syringe administer into the nasogastric or gastric feeding tube.
• After the plecanatide mixture administration is over, flush the nasogastric or gastric feeding tube with 10ml of water either by using the same or a fresh syringe.
• Allergic to plecanatide tablets.
• Obstruction of the gastrointestinal tract either known or mechanical.
• Children under 6 years of age because of the increased risk of severe dehydration.
• Safety is not established for the 6 to 18 age group.
• If it is of longer duration, skip the missed dose and take the next dose as per the scheduled time but do not take two tablets at the same time.
• For the patients who have swallowing difficulties, the tablets can be taken by crushing and mixing with water or applesauce.
• It can also be crushed as a powder and mixed with water for administering through a nasogastric or gastric feeding tube.
For oral administration with water:
• Place the tablet in a clean cup and add about 30ml of normal potable or room temperature water. Gently swirl for nearly 10 seconds and should be taken immediately.
• If any residue or leftover found in the cup add another 30 ml of water, swirl and take immediately.
For oral administration with applesauce:
• Powder the tablet in a clean cup and mix with 1 teaspoonful of applesauce and consume all the mixture immediately.
For administration with water through a nasogastric or gastric feeding tube:
• Place the tablet in a clean cup and add about 30ml of normal potable water at room temperature. Gently swirl for nearly 15 seconds.
• Flush the nasogastric tube or gastric feeding tube with 30ml of room temperature water and draw the plecanatide mixture by using the syringe and administer immediately.
• If any residue is left in the cup add 30ml of water to the cup, swirl for at least 15 seconds and draw the plecanatide mixture by using the same syringe administer into the nasogastric or gastric feeding tube.
• After the plecanatide mixture administration is over, flush the nasogastric or gastric feeding tube with 10ml of water either by using the same or a fresh syringe.
Dosage & When it is to be taken
• The recommended adult dosage of plecanatide is 3mg taken once daily as directed by the physician.When it is not to be taken (Contraindications)
Plecanatide should not be taken in patients• Allergic to plecanatide tablets.
• Obstruction of the gastrointestinal tract either known or mechanical.
• Children under 6 years of age because of the increased risk of severe dehydration.
• Safety is not established for the 6 to 18 age group.
What if you Miss a Dose of Plecanatide?
• In case a dose is missed, take the missed dose as early as possible if the time duration is very minimal.• If it is of longer duration, skip the missed dose and take the next dose as per the scheduled time but do not take two tablets at the same time.
