• Pirfenidone comes as a capsule to be taken by mouth.
• It is usually taken with food to avoid gastric discomfort.
• The capsules to be taken at the same time every day.
• The maximum daily dosage should not exceed 2403mg.
In treating idiopathic pulmonary fibrosis, the dosage can be started as per the following schedule:
From day 1 to 7 - 1 capsule per day
From day 7 to 14 - 2 capsules per day
From day 15 - 3 capsules per day
• Patients who miss pirfenidone for 14 days or more should restart the treatment with initial 2 week schedule to reach the full maintenance dosage schedule that starts from day 15.
• Patients who miss less than 14 days, the dosage before the interruption can be continued. They should not take two doses at the same time and more than three doses per day.
• End stage renal disease who require dialysis.
• Severe liver impairment or damage.
It is also contraindicated in patients taking fluvoxamine treatment.
• It is usually taken with food to avoid gastric discomfort.
• The capsules to be taken at the same time every day.
Dosage & When it is to be taken
• The recommended daily maintenance dosage for adults is 801mg (3 capsules of 267mg each) three times a day to be taken with food.• The maximum daily dosage should not exceed 2403mg.
In treating idiopathic pulmonary fibrosis, the dosage can be started as per the following schedule:
From day 1 to 7 - 1 capsule per day
From day 7 to 14 - 2 capsules per day
From day 15 - 3 capsules per day
• Patients who miss pirfenidone for 14 days or more should restart the treatment with initial 2 week schedule to reach the full maintenance dosage schedule that starts from day 15.
• Patients who miss less than 14 days, the dosage before the interruption can be continued. They should not take two doses at the same time and more than three doses per day.
When it is not to be taken (Contraindications)
Pirfenidone is not recommended in patients with:• End stage renal disease who require dialysis.
• Severe liver impairment or damage.
It is also contraindicated in patients taking fluvoxamine treatment.