Should be taken on an empty stomach. (Take on an empty stomach 1 hr before or 2 hr after meals, & at least 1 hr apart from any other drug, food, milk, antacid, Zn- or Fe-containing prep.)
Child: 1 month-12 years: 2.5 mg/kg bid, increased every 1-2 weeks to 10 mg/kg bid. 12-18 years: 0.75-1 g bid, max: 2 g daily for 1 years; usual maintenance 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day.
Cystine calculi- Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Lead poisoning Adult: 1-2 g daily in 3 divided doses. Continue treatment until urinary lead is stabilised at <500 mcg/day. Child: 20 mg/kg/day in 3 divided doses. Elderly: 20 mg/kg/day in 3 divided doses.
Cystinuria Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid.
Cuprimine, Depen
Dosage & When it is to be taken
Oral- Wilson's disease- Adult: Initially, 1.5-2 g daily in divided doses. Maintenance dose: 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day. Max: 750 mg/day in older adults.Child: 1 month-12 years: 2.5 mg/kg bid, increased every 1-2 weeks to 10 mg/kg bid. 12-18 years: 0.75-1 g bid, max: 2 g daily for 1 years; usual maintenance 0.75-1 g daily. Doses titrated to maintain urinary copper excretion >2 mg/day. Patients should receive pyridoxine supplementation 25 mg/day.
Cystine calculi- Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Lead poisoning Adult: 1-2 g daily in 3 divided doses. Continue treatment until urinary lead is stabilised at <500 mcg/day. Child: 20 mg/kg/day in 3 divided doses. Elderly: 20 mg/kg/day in 3 divided doses.
Cystinuria Adult: 1-4 g daily in 4 divided doses. Usual dose: 2 g/day. If 4 equal doses are not possible, give largest dose at bedtime. Doses adjusted to limit cystine excretion to 100-200 mg/day (<100 mg/day with history of stone formation). Patients should receive pyridoxine supplementation 25 mg/day.
Child: 1 month-12 years: 5-10 mg/kg bid, 12-18 years: 0.5-1.5 g bid.
When it is not to be taken (Contraindications)
Contraindicated to pregnancy and breast feeding, patients with history of moderate to severe kidney problem, prior penicillamine induced bone marrow problem, severe allergic reactions.Drug Name : Penicillamine
This medication is a chelating agent (remove heavy metals from the body), prescribed for Wilson disease (excess copper in the body), severe rheumatoid arthritis that has not responded to other treatments, and cystinuria (excess amino acids in the urine, which causes kidney stones).Trade Names/Brand Names of Penicillamine
India :
International :
Cuprimine, Depen
