Dosage & When it is to be taken

Single-Dose Short Test- For Outpatients: The recommended dose is 30 mg/kg (maximum 3 g) at midnight with yogurt or milk.
Multiple-Dose Test- Day 1: Control period - Collect 24-hour urine for measurement of 17-OHCS or 17-KGS.
Day 2: ACTH test to determine the ability of adrenals to respond - Standard ACTH test such as infusion of 50 units ACTH over 8 hours and measurement of 24-hour urinary steroids. If results indicate adequate response, the test may proceed.
Day 3-4: Rest period.
Day 5: Administration: Recommended with milk or snack.
Adults: 750 mg orally, every 4 hours for 6 doses. A single dose is approximately equivalent to 15 mg/kg.
Children: 15 mg/kg orally every 4 hours for 6 doses. A minimal single dose of 250 mg is recommended.
Day 6: After administration - Determination of 24-hour urinary steroids for effect.
The results will be interpreted.

When it is not to be taken (Contraindications)

Contraindicated in patients with adrenal cortical insufficiency or hypersensitivity.

Drug Name : Metyrapone

This medication is an endogenous inhibitor used in diagnosis of adrenal insufficiency and in the treatment of Cushing's syndrome (excess amount of cortisol in the body).