Guselkumab comes as a clear liquid of subcutaneous injection (100mg/ml) in a pre-filled syringe intended for single use.
• The injection sites are front thighs, back of upper arms or lower abdomen but avoiding exactly 2 inches or 5 cm around the navel area.
• The injections should not be given into tender, red or bruised, hard, thick or scaly skin affected by psoriasis.
• Before injecting, the injection should be removed from the refrigerator and allowed to reach the room temperature for 30 minutes.
• The solution should be checked for intact seal, clarity or presence of visible matter before injecting.
• When a dose is missed, it should be taken as soon as the patient remembers and the patient should continue with the next dose as per the dosing schedule.
• Allergy to the drug
• Present history of active tuberculosis
• Weak immune system
• Presence of opportunistic infections
• The injection sites are front thighs, back of upper arms or lower abdomen but avoiding exactly 2 inches or 5 cm around the navel area.
• The injections should not be given into tender, red or bruised, hard, thick or scaly skin affected by psoriasis.
• Before injecting, the injection should be removed from the refrigerator and allowed to reach the room temperature for 30 minutes.
• The solution should be checked for intact seal, clarity or presence of visible matter before injecting.
Dosage & When it is to be taken
• The recommended adult dose is 100mg of guselkumab as a subcutaneous injection taken once every 4 weeks during the first two doses and continued once for every 8 weeks thereafter for further doses.• When a dose is missed, it should be taken as soon as the patient remembers and the patient should continue with the next dose as per the dosing schedule.
When it is not to be taken (Contraindications)
Guselkumab should not be used in patients with:• Allergy to the drug
• Present history of active tuberculosis
• Weak immune system
• Presence of opportunistic infections
