How to Take Ezetimibe and Simvastatin and Dose of Ezetimibe and Simvastatin


Find out how to take Ezetimibe and Simvastatin (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Ezetimibe and Simvastatin


How it should be taken  

It comes as a capsule to take by mouth, with or without food.

Dosage & When it is to be taken

Adult- PO- The recommended usual starting dose is 10/20 mg/day. The dosage range is 10/10 mg/day through 10/80 mg/day.

When it is not to be taken (Contraindications) 

Contraindicated in patients with liver enzyme abnormalities, during pregnancy and breastfeeding, and hypersensitivity.
It should not be co-administered with CYP3A4 inhibitors.

Why it is prescribed (Indications)  

This combination medication contains an antihyperlipidemic agent and an HMG-CoA reductase inhibitor, prescribed for high cholesterol with diet. 

Pregnancy Category

Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Warnings and Precautions  

Caution should be exercised in patients with history of low blood pressure, sugar, thyroid deficiency, muscle cramps, hormonal, or electrolyte problems, seizures, kidney, or liver disease, alcohol abuse, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It may cause dizziness or changes in vision, do not drive a car or operate machinery while taking this medication.
Proper dental care is needed while taking this medication.
Monitor blood cholesterol levels, liver function, and creatine phosphokinase (CPK) blood level regularly while taking this medication.

Storage Conditions  

Store it at room temperature (20-25C).

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