• Etelcalcetide comes as a solution which has to be injected intravenously as a bolus.
• It should not be mixed or diluted before administration.
Initial dose:
• The 5mg injection is administered as an intravenous bolus injection three times a week at the end of hemodialysis procedure.
• The dose can be increased by 2.5 to 5 mg every 4 weeks till the parathyroid hormone and serum calcium levels are normal.
Maintenance dose:
• The maintenance dose varies from 2.5mg to 15mg three times a week.
Switching from Cinacalcet:
• Cinacalcet therapy should be stopped 1 week before starting etelcalcetide treatment.
• Patients allergic to etelcalcetide drug
• Pregnancy and breastfeeding women
• Patients with low blood calcium levels
• Parathyroid carcinoma
• Primary hyperparathyroidism
• Chronic kidney disease but not on hemodialysis
• Initiate etelcalcetide therapy only at the end of the next hemodialysis treatment.
• When an etelcalcetide dose is missed for more than 2 weeks, then re-initiate the treatment with a dose of 5 mg, or 2.5 mg if it was the patient’s last dose.
• It should not be mixed or diluted before administration.
Dosage & When it is to be taken
• The recommended adult dose is as follows:Initial dose:
• The 5mg injection is administered as an intravenous bolus injection three times a week at the end of hemodialysis procedure.
• The dose can be increased by 2.5 to 5 mg every 4 weeks till the parathyroid hormone and serum calcium levels are normal.
Maintenance dose:
• The maintenance dose varies from 2.5mg to 15mg three times a week.
Switching from Cinacalcet:
• Cinacalcet therapy should be stopped 1 week before starting etelcalcetide treatment.
When it is not to be taken (Contraindications)
Etelcalcetide is not recommended in• Patients allergic to etelcalcetide drug
• Pregnancy and breastfeeding women
• Patients with low blood calcium levels
• Parathyroid carcinoma
• Primary hyperparathyroidism
• Chronic kidney disease but not on hemodialysis
What if you Miss a Dose of Etelcalcetide?
• If a scheduled hemodialysis procedure is missed, do not administer etelcalcetide.• Initiate etelcalcetide therapy only at the end of the next hemodialysis treatment.
• When an etelcalcetide dose is missed for more than 2 weeks, then re-initiate the treatment with a dose of 5 mg, or 2.5 mg if it was the patient’s last dose.
