How it should be taken
Atezolizumab comes in the form of an intravenous injection to be diluted in 0.9% sodium chloride and administered into the vein. Do not co-administer other drugs in the same infusion line.
Dosage & When it is to be taken
The recommended dose of atezolizumab is 1200mg to be administered over one hour in the form of an intravenous infusion for every 3 weeks. If the first infusion is tolerated without adverse reactions, the following infusions can be given over 30 minutes. Atezolizumab should not be administered as an intravenous push or bolus.
When it is not to be taken (Contraindications)
The use of atezolizumab may have to be discontinued in patients who are allergic to the drug, or experience severe immune-related side effects that result in inflammation of the lung, liver, colon, hormone-secreting glands or other organs, infections or nervous disorders like myasthenia gravis during treatment. It should not be administered during pregnancy and breastfeeding.
Warnings and Precautions
• Do not use atezolizumab if there is any sign of immune-related pneumonia, hepatitis, endocrine problems or life threatening colitis and pancreatitis.
• Atezolizumab should be strictly avoided during pregnancy as it may cause fetal harm. Effective contraception should be used by females of reproductive age.
• Discontinue the drug if there is any signs of eye inflammation and other infusion-related reactions.
Atezolizumab does not contain any preservative and therefore should be administered immediately after preparation. If diluted, it has to be stored at room temperature for not more than 6 hours following the preparation. It can be stored in a refrigerator at 2°C - 8°C for not more than 24 hours. Do not freeze and do not shake.