How to Take Aprotinin and Dose of Aprotinin


Find out how to take Aprotinin (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Aprotinin


How it should be taken  

It comes as a solution for injection, to be administered by a healthcare provider into the vein.

Dosage & When it is to be taken

The 1ml initial (test) dose should be administered intravenously at least 10 minutes before the loading dose.
Adult: IV- 5 lac KIU (Kallikrein in activator unit) initially, followed by 2 lac KIU every 4 hour.

When it is not to be taken (Contraindications) 

Hypersensitivity.

Why it is prescribed (Indications)  

This product is derived from bovine lung tissue, which inhibits certain enzymes that increase the risk for bleeding. This medication is a protease inhibitor, prescribed for reducing blood loss and the need for blood transfusion in patients undergoing complex surgery, such as heart and liver surgery.  

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Warnings and Precautions  

Test dose is recommended to all patients to assess the risk of hypersensitivity.
Caution should be exercised in patients with history of heart surgery, liver or kidney disease, allergy, during pregnancy and lactation.
The loading dose should be given intravenously to patients in the supine position over a 20-30 minute period. Rapid intravenous administration can cause a transient fall in blood pressure.
Pediatric use is not recommended. Patient may develop with increased risk of severe allergic reactions if it is administered within 12 months of previous use of this medication.

Storage Conditions  

Store at 2-25C. Avoid freezing.

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