How to Take Aprepitant and Dose of Aprepitant


Find out how to take Aprepitant (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Aprepitant


How it should be taken  

It comes as a capsule to take by mouth, with or without food.

Dosage & When it is to be taken

PO- The recommended dose is 125 mg, 1 hour prior to chemotherapy treatment (Day 1) and 80 mg orally once daily in the morning on Days 2 and 3.
The recommended oral dosage for post operative nausea is 40 mg within 3 hours prior to induction of anesthesia.

When it is not to be taken (Contraindications) 

Contraindicated in patients who are taking astemizole, cisapride, pimozide, or terfenadine and hypersensitivity.

Why it is prescribed (Indications)  

This medication is an antiemetic, prescribed for prevention of acute and delayed chemotherapy-induced nausea and vomiting (CINV) for prevention of postoperative nausea and vomiting and it is used with other medications to prevent nausea and vomiting that may occur within 24 hours after receiving cancer chemotherapy treatment. Aprepitant works by blocking one of the body's natural substances (substance P/neurokinin 1) that causes vomiting  

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Warnings and Precautions  

Caution should be exercised in patients with history of nausea or vomiting, liver disease, any allergy, who are taking other medications, during pregnancy and breastfeeding.
Do not take aprepitant if you are on following medications, astemizole, cisapride, pimozide, or terfenadine.
It may cause dizziness, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.

Storage Conditions  

Store it at room temperature (20-25C).
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