How it should be taken
It comes as a tablet to take by mouth, with or without food.
Dosage & When it is to be taken
PO- The recommended dose is 5 mg twice daily.
Decrease dose to 2.5 mg PO BID in following conditions
- while coadministrating strong dual inhibitors.
- age ≥ 80 years
- body weight ≤ 60 kg
- serum creatinine ≥ 1.5 mg/dL
When it is not to be taken (Contraindications)
Contraindicated in patients with active pathological bleeding and hypersensitivity. It should not be co-administered with unfractionated heparin (UFH), enoxaparin and dalteparin, fondaparinux, and oral anticoagulants.
Why it is prescribed (Indications)
This medication is an anticoagulant, which is used for reducing the risk of strokes and blood clots in patients with atrial fibrillation who have no problems with their heart valve (nonvalvular atrial fibrillation).
Category B :
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Warnings and Precautions
Caution should be exercised in patients with history of kidney or liver problems, bleeding problems, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
Patients already taking 2.5 mg BID, avoid coadministration with strong dual inhibitors.
Discontinuing eliquis in patients without adequate continuous anticoagulation increases risk of stroke.
Apixaban should be stored at room temperature between 15 C to 30 C (59 F to 86 F).