How to Take Antithrombin- Recombinant and Dose of Antithrombin- Recombinant


Find out how to take Antithrombin- Recombinant (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Antithrombin- Recombinant


How it should be taken  

It comes as solution for injection to be administered by a healthcare provider into the vein.

Dosage & When it is to be taken

Dose is based on based on the patient's pretreatment functional AT activity level and body weight.
Adult- IV- The recommended initial dose is 30-50 IU/kg. Adjust dose according to response.
Administer loading dose as a 15-minute intravenous infusion immediately followed by continuous infusion of the maintenance dose.

When it is not to be taken (Contraindications) 

Hypersensitivity to any ingredient in antithrombin (recombinant), or to goat or goat milk proteins.

Why it is prescribed (Indications)  

This medication is a recombinant human antithrombin, prescribed for prevention of surgical and peri-partum thromboembolic events in hereditary antithrombin deficient patients. It works by regulating the clotting and inflammatory processes that lead to the formation of blood clots. 

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution needed for pregnant, breastfeeding women, if you are taking any other medicines, especially any of the anticoagulants (eg, heparin) because the risk of bleeding may be increased by antithrombin (recombinant).
Monitor AT-III levels during treatment.
It may cause dizziness or lightheadedness, do not drive a car or operate machinery while taking this medication.

Storage Conditions  

Store it in refrigerator (2-8C). Do not freeze it. Bring vials to room temperature no more than 3 hours prior to reconstitution.

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