How to Take Anakinra and Dose of Anakinra


Find out how to take Anakinra (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Anakinra


How it should be taken  

It comes as a solution for injection, administered subcutaneously by a healthcare provider once a day, at the same time every day.

Dosage & When it is to be taken

SC- The recommended dose is 100 mg/day. Dose reduction to 100 mg s.c. every other day should be considered in patients with severe renal impairment.
Cryopyrin-Associated Periodic Syndromes (CAPS) - The recommended starting dose is 1-2 mg/kg for NOMID patients. The dose can be individually adjusted to a maximum of 8 mg/kg daily to control active inflammation.

When it is not to be taken (Contraindications) 

Hypersensitivity to Escherichia coli -derived proteins, anakinra, or any component of product. Contraindicated to preexisting malignant diseases (e.g., solid cancers, leukemia) patients with neutropenia due to any reason, severely impaired renal function and preexisting active tuberculosis. Should not be used in combination with anti-TNF agents.

Why it is prescribed (Indications)  

This medication is a recombinant human interleukin 1 antagonist, prescribed for reducing the pain and swelling associated with moderate to severe rheumatoid arthritis either alone or in combination with methotrexate to patients (18 years or older) who have had an absence of clinical improvement of symptoms or inadequate response in therapy with one or more disease-modifying anti-rheumatic drugs (DMARDs). It inhibits the binding of the interleukin 1 to its receptor. It is sometimes used for adult-onset still's disease, gout and pseudogout, juvenile arthritis, ankylosing spondylitis, uveitis, and auto-inflammatory syndromes. 

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Warnings and Precautions  

Avoid vaccination while taking this medication.
Swelling or bruising at the injection site occurs; apply a cold pack on the injection site immediately after injection.
It should not be used in children.
Caution needed for patients with history of infection, asthma, HIV infection or AIDS, or kidney disease, during pregnancy and breast feeding.
Do not reuse needles, syringes, or other materials.

Storage Conditions  

Store it in refrigerator (2 to 8C) and warmed to room temperature before use. Do not freeze or shake it. Keep away from children and protect from light.
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