How to Take Ampicillin and Sulbactam and Dose of Ampicillin and Sulbactam


Find out how to take Ampicillin and Sulbactam (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Ampicillin and Sulbactam


How it should be taken  

It comes as a solution for injection, to be administered by a healthcare provider into the large muscle or the vein. It also comes as a tablet for oral use.

Dosage & When it is to be taken

Dose is based on ampicillin dose. IV Endocarditis 2g 6 hourly for 4-6 week with gentamicin or vancomycin. Aspiration, community-acquired pneumonia 1-2g 6 hourly. Hospital-acquired pneumonia 2g 6 hourly. IV/IM Susceptible infections 1-2g 6 hrly. Max: 8 g/day. Uncomplicated gonorrhoea 1-2g as single dose, may use with oral probenecid. Acute pelvic inflammatory disease 2g 6 hourly with IV or oral doxycycline. Discontinue parenteral treatment 24 hr after clinical improvement; continue oral doxycycline to complete 14 days of treatment. The total dose of sulbactam should not exceed 4gms per day.
Pediatric Patients 1 year of age or older recommended dosage is 300 mg per kg of body weight administered via IV infusion in equally divided doses every 6 hours.

When it is not to be taken (Contraindications) 

Allergic to penicillins, infectious mononucleosis (kissing disease).

Why it is prescribed (Indications)  

This medication is a penicillin antibiotic, prescribed for susceptible bacterial infections like skin infections, gynecological infections or infections of the abdomen either alone or with other medications. It blocks the bacteria's cell wall growth, which kills the bacteria. Sulbactam blocks the enzyme, which breaks down ampicillin and thereby allows ampicillin to attack and kill the bacteria. 

Pregnancy Category

Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Warnings and Precautions  

Monitor for signs of anaphylaxis, blood count, kidney and liver function, signs of super infections with mycotic or bacterial pathogens during treatment.
Prolonged use may increase the risk of fungal infection.
Caution needed during pregnancy and lactation.
It should not be mixed with aminoglycosides while administering into the vein.

Storage Conditions  

Store dry powder at 20-25�C. Store it at room temperature. Refrigerate suspension. Do not freeze. Discard after 14 days because the medicine loses its potency.
Place the medication in room temperature for 1 hour prior to use.
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