How it should be taken
It comes as a fluid for IV injection, administered by infusion into the vein by a health care professional once a day. It may be administered orally for fungal infection of the intestines or as eardrops for fungal infection of the ears.
Dosage & When it is to be taken
Following a test dose, treatment is started with an IV dose of 0.3 mg/kg/day injected slowly. Usual dose 0.7 mg/kg. Dose in fungal meningeal infections - 0.5 mg twice weekly administered intrathecally. Since the lipid amphotericin B formulation have lower side effects, they may be administered in higher doses.
When it is not to be taken (Contraindications)
Hypersensitivity, lactation, do not give to patients receiving antineoplastics (cancer drugs).
Why it is prescribed (Indications)
This medication is an antibiotic, prescribed for life-threatening fungal infections.
It is also effective in treating leishmaniasis. Newer preparations of this medication with lipid are now available which show lesser side effects than the older preparations.
Category B :
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Warnings and Precautions
Do not use this medication for less severe infections such as oral thrush (white spots in the mouth), vaginal yeast infections, throat infections (esophageal), nor for localized (not spread throughout the body) fungal infections in people with a normal white blood count.
Caution needed in patients receiving transfusions, or have ever had diabetes or kidney disease, pregnancy.
Breastfeeding is contraindicated in patients receiving treatment with liposomal Amphotericin B.
Intrathecal: Store at 2-8°C. Protect from light and do not freeze it.
IV: Store it in refrigerator and protect from light and do not freeze it.