How to Take Amitriptyline and Perphenazine and Dose of Amitriptyline and Perphenazine


Find out how to take Amitriptyline and Perphenazine (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Amitriptyline and Perphenazine


How it should be taken  

It comes as a tablet to take by mouth, with or without food.

Dosage & When it is to be taken

Adults - PO- Initially, usual dose is 2 to 4 mg perphenazine with 10 to 50 mg amitriptyline 3 to 4 times daily.

When it is not to be taken (Contraindications) 

Contraindicated in patients with brain damage, blood disorders, liver damage, recent heart attack, blood disorder, who are taking depressants, who have taken monoamine oxidase inhibitor (MAOI) within last 14 days and hypersensitivity.

Why it is prescribed (Indications)  

This medication is a phenothiazine and tricyclic antidepressant combination, prescribed for anxiety and depression.  Serotonin and noradrenaline reabsorption prevent by Amitriptyline where as Perphenazine blocks a variety of receptors in the brain

Pregnancy Category

Category N : Not yet classified.

Warnings and Precautions  

Caution should be exercised in patients with history of breast cancer, seizures, asthma or other breathing problems, trouble in urinating, alcohol abuse, depression, suicidal thoughts, lung infection, heart disease, Reye syndrome, Parkinson disease, increased eye pressure, high/low blood pressure, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
It may cause drowsiness, dizziness or fainting, do not drive a car or operate machinery while taking this medication.
Avoid alcohol consumption.
Avoid exposure to sunlight; otherwise it may cause sunburn.
It may cause heatstroke, protect from hot weather.
This medication may develop increased risk of suicidal thoughts in children and teenagers; watch them carefully.
Patient may develop with increased risk of neuroleptic malignant syndrome (NMS) with the following symptoms: fever, muscle tightness, confusion, abnormal thinking, fast or irregular heartbeat; and sweating. If it so consult with your doctor.
Etrafon should not be discontinued suddenly. Dosage should be tapered gradually, especially following long-term treatment, to minimize withdrawal symptoms.
When a medication containing perphenazine is taken for a long time, patients are advised to take a riboflavin (vitamin B2) supplement.

Storage Conditions  

Store it at room temperature, and in an airtight container. Keep away from children. Protect unit-dose packages from excessive moisture.
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