How to Take Amitriptyline and Dose of Amitriptyline


Find out how to take Amitriptyline (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Amitriptyline


How it should be taken  

It comes as a tablet, to take by mouth, with or without food.

Dosage & When it is to be taken

Adult: PO- Depression- Initial:50-75 mg/day; up to 150 mg/day if needed. Max: 300 mg/day in severe cases.
Neuropathic pain- Initial: 10-25 mg/day at night, up to 75 mg/day if needed.
Migraine prophylaxis- Initial: 10 mg/day at night. Maintenance: 50-75 mg/day at night.

When it is not to be taken (Contraindications) 

Contraindicated in patients who are taking antihistamines, or who have taken MAOIs within the last 14days and hypersensitivity.

Why it is prescribed (Indications)  

This medication is a tricyclic antidepressant, prescribed for depression. It is also prescribed for migraine and nerve pain.  It corrects the imbalance of chemical substances acting on the nervous system.

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution should be exercised in patients with history of irregular heartbeat, heart disease, chest pain, liver disease, prostate problems, overactive thyroid, urinary retention, suicidal thoughts, alcohol addiction, any allergy, who are taking other medications, elderly, during pregnancy and breastfeeding.
It may cause dizziness, drowsiness or blurred vision, do not drive a car or operate machinery, get up slowly from bed while taking this medication.
Avoid alcohol consumption.
Patient may develop with involuntary muscle movements; if it so consult with your doctor immediately.
Avoid prolonged exposure to sunlight.
It may cause heatstroke, protect from hot weather.

Storage Conditions  

Store it at room temperature, and in an airtight container. Keep away from children.

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