How to Take Amiodarone and Dose of Amiodarone

Find out how to take Amiodarone (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Amiodarone

How it should be taken  

It comes as a tablet to take by mouth. It is usually taken once or twice a day with or without food. (Take consistently with or without meals. Take with meals if high dose or to reduce GI discomfort.). Injection administered into the vein by a health care provider.

Dosage & When it is to be taken

Oral:Ventricular arrhythmias- Adult: 800-1,600 mg/day in 1-2 divided doses for 1-3 week until initial therapeutic response is achieved then reduce dose to 600-800 mg/day in 1-2 divided doses for 1 month. Maintenance: 400 mg/day; lower doses may be used for supraventricular arrhythmias. Close monitoring of the patient is recommended. Use the minimum effective dose. Liver impairment: Dosage reduction may be necessary.
IV Recommended starting dose is approximately 1,000 mg over the first 24 h administered as follows: rapid administration of 150 mg over first 10 min (15 mg/min), followed by 360 mg over next 6 h (1mg/min), then 540 mg over remaining 18 h (0.5 mg/min). After first 24 h, continue maintenance infusion rate of 0.5 mg/min (720 mg/24 h).

When it is not to be taken (Contraindications) 

It should not be administered to patients allergic to the drug or to iodine, pregnant women, shock due to a cardiac cause, and some heart conditions such as sinus node dysfunction and severe heart block.

Why it is prescribed (Indications)  

This medication is used to treat life-threatening irregular heart rhythms (arrhythmias) and to maintain a normal heart rate in patients who have not responded to other medications. It is an antiarrhythmic drug.  

Pregnancy Category

Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Close monitoring is recommended as AMIODARONE may worsen arrhythmia especially when used concurrently with other anti-arrhythmic drugs or drugs that prolong QT interval.
Corneal refractive laser surgery is not recommended in patients on amiodarone treatment. Due to corneal microdeposits, Drivers are not advised to drive at night as they may be dazzled by headlights.
It may cause hypotension and slow heart beat, increase risk of liver toxicity, visual disturbance/impairment; lung damage; monitor for pulmonary toxicity e.g. acute respiratory distress syndrome.
Monitor liver functions regularly.
It may affect defibrillation or pacing thresholds of cardiac devices.
Correct electrolyte imbalance before starting treatment.
Caution when used in patients undergoes surgery, hepatic impairment, thyroid disease, elderly, breast feeding.

Storage Conditions  

Injection: Store at 15-25C. Store it in airtight container and keep away from children.

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