How to Take Ambrisentan and Dose of Ambrisentan


Find out how to take Ambrisentan (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Ambrisentan


How it should be taken  

It comes as a tablet to take by mouth, with or without food.

Dosage & When it is to be taken

PO- The initial recommended dose is 5mg once daily with or without food. Maximum: 10mg once daily.

When it is not to be taken (Contraindications) 

Contraindicated in patients with Idiopathic Pulmonary Fibrosis (IPF), pregnant women and known hypersensitivity. It should not be co-administered with cyclosporine.

Why it is prescribed (Indications)  

This medication is an endothelin receptor antagonist, prescribed for pulmonary atrial hypertension (high blood pressure in the lungs). The medication blocks the effects of endothelin-1 thereby decreases blood pressure in lungs. The medication also inhibits the thickening of the blood vessel.  

Pregnancy Category

Category X : Studies in animals or humans have demonstrated fetal abnormalities and/or there is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience, and the risks involved in use of the drug in pregnant women clearly outweigh potential benefits.

Warnings and Precautions  

Caution should be exercised in patients with history of liver or kidney impairment, decreased sperm count, fluid retention, during breastfeeding.
Monitor liver function, complete blood count regularly while taking this medication.

Storage Conditions  

Store it at room temperature (25C), and in an airtight container.

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