How it should be taken
It comes as a capsule to take by mouth, before surgery.
Dosage & When it is to be taken
Adults- PO- The recommended dose is 12 mg 30 min to 5 hours prior to surgery followed by 12 mg twice daily beginning the day after surgery for a max of 7 days or until discharge.
When it is not to be taken (Contraindications)
Contraindicated in patients who have taken opioids for more than 7 consecutive days before taking this medication.
Why it is prescribed (Indications)
This medication is an opioid receptor blocker, prescribed for bowel recovery (postoperative ileus) more quickly after bowel surgery.
Category B :
Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.
Warnings and Precautions
Caution should be exercised in patients with history of liver or kidney disease, who have taken opioids for chronic pain, bowel obstruction, who are taking other medications, any allergy, during pregnancy and breastfeeding.
Monitor blood counts and potassium levels regularly while taking this medication.
Store it at control room temperature (25°C).