How to Take Alteplase and Dose of Alteplase


Find out how to take Alteplase (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Alteplase


How it should be taken  

It comes as a solution for injection, to be injected by a healthcare provider into the vein.

Dosage & When it is to be taken

Adult: Acute massive pulmonary embolism- Total dose: 100 mg (not >1.5 mg/kg for patients weighing <65 kg). 10 mg as bolus, followed by infusion of the remainder dose over 2 hour.
Acute stroke: 0.9 mg/kg (not more than 90 mg) IV over 1 hour. The first 10% should be administered in 1 minute.
Heart attack: For patients weighing > 67 kg, 15 mg iv, followed by 50 mg over the next half an hour, and then 35 mg over the next 1 hour. The total dose of 100 mg may also be administered over 3 hours.

When it is not to be taken (Contraindications) 

Contraindicated in patients with recent surgery or trauma, bleeding within the brain, uncontrolled high blood pressure, clotting defects, aneurysm or tumor in brain and active bleeding.

Why it is prescribed (Indications)  

This medication is an enzyme (tissue plasminogen activator (tPA)), prescribed for heart attack, stroke, and pulmonary embolism. It helps to break down unwanted blood clots.  

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

It may lead to serious bleeding, contact your doctor immediately.
Caution should be exercised in children, elderly, pregnant women, and patients with kidney disease.
Monitor for intracranial bleeding and blood pressure in acute stroke.

Storage Conditions  

Injection: Store it at room temperature (<30C) or under refrigeration.
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