How to Take Allopurinol and Dose of Allopurinol


Find out how to take Allopurinol (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Allopurinol


How it should be taken  

It comes as a tablet to take by mouth, with food.

Dosage & When it is to be taken

Adult: PO- Gout and Hyperuricaemia- Initial: 100 mg/day, may adjust dose according to response. Max: 800 mg/day.
Prevention of hyperuricaemia associated with chemotherapy treatment or enzyme disorders- 600-800 mg/day, starting 2-3 days before cancer treatment.
IV- Gout and Hyperuricaemia: As Na: 200-400 mg/m2/day. Max: 600 mg/day.

When it is not to be taken (Contraindications) 

Hypersensitivity.

Why it is prescribed (Indications)  

This medication is a xanthine oxidase inhibitor, prescribed for gout. It is used to treat high uric acid levels in the blood or urine caused by certain types of cancer chemotherapy. 

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution should be exercised in patients with history of kidney or liver diseases, heart problems, bone marrow problems, high blood pressure, diabetes, who are taking other medication, any allergy, children, during pregnancy and breastfeeding.
It may cause drowsiness, do not drive a car or operate machinery while taking this medication.
Monitor kidney and liver function regularly while taking this medication.

Storage Conditions  

Store it at controlled room temperature (15 to 25C) and in an airtight container.
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