How it should be taken
It comes as a powder for injection (diluted with fluid) to be administered by a healthcare provider into the vein.
Dosage & When it is to be taken
IV- 600,000 units/kg every 8 h by a 15 min infusion for 14 doses. Repeat regimen after 9 days of rest, the schedule is repeated for another 14 doses, for a maximum of 28 doses per course, as tolerated.
When it is not to be taken (Contraindications)
Contraindicated in patients who have a history of an abnormal heart stress test or lung function test, heart rate or rhythm, re-treatment in patients who have experienced with drug-related toxicities.
Why it is prescribed (Indications)
This medication is an antineoplastic agent, prescribed for metastatic renal cell carcinoma.
It is a man-made version of a substance called interleukin-2 which are produced naturally by cells in the body. Aldesleukin is also used to treat melanoma (a type of skin cancer) that has spread to other parts of your body.
Category C :
Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.
Warnings and Precautions
Caution should be exercised in patients with history of heart, lung, brain, kidney, liver, or autoimmune disease, infection, central nervous system disorder, any allergy, who are taking other medications, during pregnancy and breastfeeding.
It should be restricted to patients with normal cardiac and pulmonary functions as defined by thallium stress testing and formal pulmonary function testing.
It may cause drowsiness or dizziness, do not drive a car or operate machinery while taking this medication.
It may reduce platelet counts; avoid injury or bruising.
Avoid contact with people who have infections.
Monitor complete blood cell counts, kidney and liver tests, and lung function tests regularly while taking this medication.
Should be stored in a refrigerator at 2 C to 8 C (36 F to 46 F) before and after reconstitution with diluent. Do not freeze.