How to Take Acetazolamide and Dose of Acetazolamide

Find out how to take Acetazolamide (drug) and its dose. Describes the best time to take the drug and precautions if any that should be followed.

How to take Acetazolamide

How it should be taken  

It comes as a tablet and capsule, to take by mouth with food. If you are taking the extended-release form of acetazolamide, do not crush or chew the capsules.

Dosage & When it is to be taken

The dose ranges from 250 mg to 1 g of acetazolamide for 24 hours, usually in divided doses for amounts over 250 mg.
Adult- PO Diuresis 250-375 mg/day. Glaucoma; Epilepsy 250-1,000 mg/day. Prophylaxis of high altitude sickness 500-1,000 mg/day. IV Chronic open angle glaucoma 250-1000 mg 24 hrly and Epilepsy 8-30 mg/kg/day in divided doses.

When it is not to be taken (Contraindications) 

Contraindicated in patients with adrenal gland problems, low levels of potassium or sodium in blood, kidney problems, liver problems, high levels of chloride in blood, electrolyte problems and hypersensitivity.

Why it is prescribed (Indications)  

This medication is a carbonic anhydrase inhibitor, prescribed for glaucoma, edema due to congestive heart failure, epileptic seizure, idiopathic intracranial hypertension (a.k.a. pseudotumor cerebri), cystinuria, periodic paralysis, central sleep apnea and dural ectasia. It is also used to prevent and reduce the symptoms of altitude or acute mountain sickness and moderate to severe metabolic or respiratory alkalosis. This medication reduces the activity of carbonic anhydrase protein. 

Pregnancy Category

Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Warnings and Precautions  

Caution should be exercised in patients with history of kidney stones, sickle cell anemia, lung diseases, increased eye pressure, respiratory problem, elderly, who are taking other medications, any allergy, during pregnancy and breastfeeding.
It may cause dizziness, drowsiness or vision changes, do not drive a car or operate machinery while taking this medication.
Limit alcoholic beverages.
Avoid exposure to sunlight.
Monitor blood sugar, complete blood cell count regularly while taking this medication.
This medication should not be used in children less than 12 because it may affect normal growth.
Caution is advised for patients receiving concomitant high-dose aspirin and acetazolamide, as anorexia, tachypnea, lethargy, coma and death have been reported.

Storage Conditions  

Store at 20-25C (68-77F). Excursions permitted to 15-30 in an airtight container. Keep it out of reach of children.

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