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Methotrexate

Drug Name :  Methotrexate


Indication :Widely used anticancer drug acting as an antimetabolite in DNA synthesis.


Physiology :Methotrexate is an antimetabolite that combines with dihydrofolate reductase and interferese with the synthesis of tetrahydrofolic acid necessary for DNA synthesis.


Normal Values :Normal values depend upon the drug therapy.


Critical Values :>2.27 µg/mL (> 5 µmol/L)


Test Method :Enzyme immunoassay, Radio immunoassay, HPLC


Side effects :Combination of salicylate administration increases incidence of toxicity, due to diminished renal tubular excretion.




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