Drug Name : Maprotiline
Indication :Maprotiline is an antidepressant. This test is done to ealuate toxicity and drug level monitoring of Maprotiline
Physiology :Maprotiline is a tetracyclic antidepressant prescribed for depression, schizophrenia, idiopathic pain. Maprotiline is a potent inhibitor of of norepinephrine to presynatptic nerve terminal.
Normal Values :200-600 ng/mL (721-2163 nmol/L)
Critical Values :>1000 ng/mL (> 3605 nmol/L)
Test Method :High performance liquid chromatography, Gas chromatography.
Side effects :Anticholinergic activity, Cardiovascular toxicity. At overdoses may cause coma, convulsions, dysrhythmias, hypotension.