Amikacin/ Amikin - Drug Toxicity

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Latest prescription information about Amikacin/ Amikin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
Drug Name : Amikacin/ Amikin

Indication : Aminoglycoside antibiotics, including amikacin, are used primarily to treat infections caused by aerobic gram-negative bacilli. Peak levels are necessary to assure adequate therapeutic levels for organism being treated.


Physiology : Amikacin is cleared by the kidney and accumulates in renal tubular cells.

Normal Values : Therapeutic peak: 15-25 mg/mL (26-43 mmol/L).

Critical Values : Critical values: Toxic: Peak - > 35 mg/mL (>60 mmol/L), Intermediate: >10 mg/mL (>17 mmol/L).


Test Method : High performance Liquid Chromatography (HPLC), Enzyme Immunoassay (EIA).

Side effects : Chronic use of amikacin leads to nephrotoxicity or damage to kidneys resulting in elevated levels of creatinine in the blood and oliguria (low output of urine). Ototoxicity may also occur resulting in hearing loss and loss of balance. Neuromuscular blockade and respiratory paralysis has been also reported when the drug is injected into the abdomen or the chest. Caution is advised when the drug is administered in patients undergoing anesthesia or those with Parkinsonís disease or myasthenia gravis.

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