Zaltoprofen is an effective propionic acid derivative (similar to Ibuprofen molecule) NSAID (Non-Steroidal Anti-Inflammatory Drug) which is used to treat various pain, musculoskeletal and joint disorders.
Zaltoprofen is a nonsteroidal anti-inflammatory drug. It is a preferential COX-2 inhibitor which selectively inhibits the production of prostaglandin E2 (a physiologically active biological compound) at inflammatory sites and therefore reduces pain and inflammation. In addition, it inhibits bradykinin-(an agent that mediates pain and inflammation) induced pain responses.
Zaltoprofen is prescribed for treating pain and inflammatory conditions caused by various disorders such as dental pain, musculoskeletal pain, post-operative pain, lumbar pain, frozen shoulder, osteoarthritis and cervicobrachial syndrome.
Zaltoprofen should not be given to patients with:
• Peptic ulcer with or without a rupture in the gastrointestinal tract as the NSAID group causes gastrointestinal bleeding.
• Ulcerative colitis or Crohn's disease (inflammatory bowel disease)
• Blood abnormalities
• Cardiovascular disease as some cardiovascular deaths have been noted with some NSAIDs.
• Asthma since it could cause an asthmatic attack.
• Allergy to the drug
• Severe liver or kidney damage
For the treatment of arthritis-related and other pain conditions:
• The recommended adult dose is 80mg three times daily.
• Zaltoprofen comes as a tablet to be taken by mouth.
• It should be taken with food to avoid gastric discomfort.
• Zaltoprofen should not be used in children, pregnant women and breastfeeding mothers because of the lack of safety and effectiveness data.
• Gastrointestinal: Loss of appetite, nausea, vomiting, dry mouth, gastric irritation and constipation
• Central Nervous System: Drowsiness, feeling of numbness and dizziness
• Skin: Sensitivity to light and itching
• Blood: Low red blood cell count and increased platelet count
• Others: Increased frequency of urination, blood in urine, pain on urination, rise in liver enzymes or creatinine level, fever
• In case of overdosage, the patient should be treated symptomatically for complications such as hypotension (decrease in blood pressure), gastrointestinal irritation, kidney damage and breathing difficulties.
• Anticoagulants: Zaltoprofen may increase the anticoagulant effects of drugs such as warfarin and heparin.
• Quinolones: Concomitant of quinolone antibacterials such as ciprofloxacin and nalidixic acid with zaltoprofen may result in convulsions.
• Antidiabetics: Zaltoprofen taken together with sulfonylurea drugs such as chlorpropamide, glipizide and gliclazide may increase the hypoglycemic action of antidiabetic drugs.
• Lithium: The dose of lithium may have to be adjusted with zaltoprofen because of the increased effects of lithium with zaltoprofen.
• Store at room temperature.
• Protect from heat and moisture.
• Keep out of reach of children.
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