Generic Name : Vorinostat Pronunciation : vor-IN-oh-stat
International- Zolinza. Why it is prescribed (Indications) :
This medication is a histone deacetylase (HDAC) inhibitor, prescribed for cutaneous T-cell lymphoma (CTCL, a type of cancer). It kills or stops cancer cell growth. When it is not to be taken (Contraindications): Hypersensitivity.
Dosage & When it is to be taken :
PO- The recommended dose is 400 mg once daily with food. How it should be taken :
It comes as a capsule to take by mouth, with food. Warnings and Precautions :
* Caution should be exercised in patients with history of kidney or liver impairment, blood clots, high blood sugar, irregular heartbeat, anemia, decrease in blood minerals, dehydration, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness or fatigue, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid injury or bruising.
* It may raise blood sugar level; monitor sugar level regularly while taking this medication.
* Monitor complete blood cell counts, blood electrolyte levels, and blood glucose levels regularly while taking this medication. Side Effects :
Gastrointestinal - Diarrhea, nausea, loss of appetite, decreased weight, vomiting, constipation and dry mouth.
Blood - Anemia, decrease in platelet counts.
Central Nervous System - Fatigue, dizziness and headache.
Miscellaneous - Chills, fluid retention, fever and cough.
* Avoid excess dosage. Storage Conditions :
Store it at room temperature (20-25°C).
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