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Vardenafil

Latest prescription information about Vardenafil. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Vardenafil
Pronunciation : var-DEN-a-fil
Therapeutic Classification : Impotent Agents
Trade Name(s): 
India- Mevitra -20, Mvitra.
International- Levitra, Staxyn.
Why it is prescribed (Indications) : 
This medication is a phosphodiesterase type 5 (PDE5) inhibitor, prescribed for erectile dysfunction (impotence). It works by increasing blood flow to the penis during sexual stimulation.
When it is not to be taken (Contraindications): Contraindicated in patients who are taking nitrate, heart disease and hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
PO- Initial- The recommended dose is 10 mg; it should be taken approximately 60 minutes before sexual activity.
It may be increased or decreased. Maximum: 20mg.
How it should be taken : 
It comes as a tablet to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of prolonged (more than 4 hours) or painful erection, who have deformed penis, peyronie's disease, diabetes, high cholesterol, high or low blood pressure, irregular heartbeat, heart attack, chest pain, stroke, epilepsy, lung problems, ulcer, bleeding disorder, blood disorder, multiple myeloma (cancer of the plasma cells), blood cancer, liver, kidney or heart disease, any allergy, who are taking other medications, elderly.
* It should be given only for men.
* Patient may experience with chest pain during sexual intercourse; if it is so consult with your doctor immediately.
* Avoid sexual activities.
Side Effects : 
Common- Headache, flushing, nose inflammation, indigestion, accidental injury, inflammation of sinus, flu syndrome, dizziness, increased level of liver enzymes and nausea.
Body As A Whole- Anaphylactic reaction (including laryngeal edema), weakness, face swelling and generalized pain.
ENT - Loss of hearing and ringing in the ear.
Heart - Chest pain, high/low blood pressure, heart attack, palpitation, fainting and fast heart rate.
Gastrointestinal - Abdominal pain, abnormal liver function tests, diarrhea, dry mouth, difficulty in swallowing, inflammation of esophagus/stomach, acid reflux and vomiting.
Musculoskeletal - Joint pain, back pain, muscle pain and neck pain.
Central Nervous System- Muscle tightness, sleeplessness, tingling, drowsiness and fatigue.
Respiratory- Difficulty in breathing, nose bleed and inflammation of pharynx.
Skin- Photosensitivity reaction, itching, rash and sweating.
Eye - Abnormal vision, blurred vision, changes in color vision, increased redness of the eye, dim vision, eye pain, increased eye pressure, sensitivity to sunlight and watery eyes.
Genitourinary - Abnormal ejaculation and prolonged or painful erections.
Other Precautions : 
* It is not advisable for women, especially during pregnancy and lactation.
Storage Conditions : 
Store it at room temperature (25°C), and in an airtight container.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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