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Triprolidine

Latest prescription information about Triprolidine. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Triprolidine
Pronunciation : trye-PROE-li-deen
Therapeutic Classification : Antihistamines And Decongestants
ICD Code : Y55.5
Trade Name(s): 
India- Actifed Plus Paediatric Susp, Actifed Plus Tab, Actifed-Dm Liqd, Symofast Syr, Teguphen Syr.
International- Zymine, Zymine XR, Tripohist.
Why it is prescribed (Indications) : 
This medication is an antihistamine, prescribed for hay fever or other allergies, such as runny nose, sneezing, itching of the nose and throat, and itchy, watery eyes either used alone or in combination of other medications. It blocks histamine action, which reduces allergy symptoms.
When it is not to be taken (Contraindications): Contraindicated to newborns, asthma patients, breastfeeding women, known hypersensitivity to codeine phosphate and other antihistamines.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Adult: PO- The recommended dose is 2.5 mg 4-6 hourly. Max: 10 mg/day.
How it should be taken : 
It comes as tablet& syrup to take by mouth, with or without food.
Warnings and Precautions : 
*Caution should be exercised in patients with history of increased eye pressure, urinary retention, enlargement of prostate, pyloric obstruction (disorder), epilepsy, children less than 6 years, elderly, during pregnancy.
*It may cause drowsiness, dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.
Side Effects : 
Most Common- Dryness of mouth, dryness of nose, dryness of throat, sedation, sleepiness, dizziness, disturbed coordination.
Body as Whole- Hives, rash, anaphylactic shock, photosensitivity, excessive perspiration and chills.
Heart- Low blood pressure, headache, palpitations, fast heart rate, abnormal heart rhythm.
Blood - Anemia, decrease in white blood cells.
Central Nervous System- Fatigue, confusion, restlessness, excitation, anxiety, nervousness, tremor, irritability, sleeplessness, emotion, tingling, blurred vision, double vision, vertigo, tinnitus, confusion, hysteria, convulsions, depression, hallucination.
Gastrointestinal - Indigestion, loss of appetite, nausea, vomiting, diarrhea, constipation.
Genitourinary - Urinary frequency, difficult urination, urinary retention, early menses.
Respiratory - Thickening of bronchial secretions, tightness of chest and wheezing, nasal stuffiness, respiratory depression.
Potentially Fatal- Blood disorder.
Other Precautions : 
*Avoid alcohol consumption while taking this medication.
Storage Conditions : 
Oral: Store between 15-30�C. Store it at room temperature and in an airtight container. Keep away from children and pets.

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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