Trimetazidine is an anti-ischemic (anti-anginal) drug, prescribed for angina pectoris.
Trimetazidine should not be used in patients with history of kidney disease, patients allergic to the drug, and patients with Parkinson disease, restless leg syndrome or other movement disorders.
Trimetazidine may be used in patients with angina as add-on therapy.
The recommended dose is 20 mg to be taken three times a day or 35 mg MR (modified release) twice a day.
It comes as a tablet to take by mouth, with food.
• Caution needed for pregnant and breastfeeding women, Patients with history of kidney disease, Parkinson disease or any other serious medical condition.
• Gastrointestinal disturbances: nausea and vomiting
• Allergy: Skin rash and hives
• Cardiovascular: Palpitations, fall in blood pressure
• Nervous system: Headache, movement disorders like drug-induced Parkinsonism with symptoms like tremors and increased muscle tone, restless leg syndrome and gait problems
• Blood: Decreased white blood cells and platelets
• Liver: Liver dysfunction
Avoid excess dosage.
Trimetazidine should be avoided with a class of drugs referred to as MAO inhibitors.
Store the tablet at room temperature.
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