Tretinoin - Drug Information

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General Information on Tretinoin

Generic Name : Tretinoin

Pronunciation : tret' i noyn

Latest prescription information about Tretinoin. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.

Why is Tretinoin Prescribed? (Indications)

This medication is a retinoid, prescribed for acne vulgaris and acute promyelocytic leukemia.  It slows or stops the growth of cancer cells in the body.

When should Tretinoin not to be taken? (Contraindications)

Hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Tretinoin?

PO- The recommended dose is 45 mg/m2/day administered as two evenly divided doses.
Topical- 0.05% apply a thin layer of cream over the affected area.

How should Tretinoin be taken?

It comes as a capsule to take by mouth, with or without food.
Topical- It comes as a liquid, cream and gel to apply topically.

What are the warnings and precautions for Tretinoin?

Caution should be exercised in patients with history of blood cholesterol, liver or heart disease, abnormally high white blood cell count, any allergy, who are taking other medications, children, during pregnancy and breastfeeding.
It may cause dizziness or severe headache, do not drive a car or operate machinery while taking this medication.
Monitor pregnancy tests, blood clotting factors, blood cholesterol and triglyceride levels, liver function and white blood cell counts regularly while taking this medication.
It should not be used in children less than 1 year old.
Topical -
Wash your hands thoroughly after applying this medication.
Avoid exposure to sunlight.
Keep away from eyes, mouth, angles of nose, mucous membranes or open wounds.

What are the side effects of Tretinoin?

   Most Common : Headache, fever, skin dryness, bone pain, nausea/vomiting, rash, itching, increased sweating, visual disturbances, hair loss, skin changes and bone inflammation.
   Body as a Whole : Uneasiness, shivering, bleeding, infections, swelling in the extremities, chest discomfort, increased and decreased weight, injection site reactions, loss of appetite, muscle pain, flank pain, fluid imbalance, pallor, lymph disorders, acidity and chills.
   Respiratory : Upper respiratory tract disorders, difficulty in breathing, respiratory insufficiency, pneumonia, wheezing, lung infection/swelling and asthma.
   ENT : Ear pain and hearing loss.
   Gastrointestinal : GI hemorrhage, abdominal pain, diarrhea, constipation, indigestion, abdominal distention, liver inflammation, ulcer and unspecified liver disorder.
   Heart : Abnormal heart rate, flushing, low/high blood pressure, vein inflammation, heart failure, heart attack, enlarged heart, heart murmur and stroke.
   Central Nervous System : Dizziness, tingling, anxiety, sleeplessness, depression, confusion, agitation, hallucinations, abnormal gait, convulsions, coma, CNS depression, speech disorder, encephalopathy, facial paralysis, tremor, leg weakness, unconsciousness, dementia, memory loss, drowsiness and slow speech.
   Genitourinary : Kidney impairment, painful urination, urinary frequency and enlarged prostate.
   Miscellaneous : Skin lesions.

What are the other precautions for Tretinoin?

Avoid excess dosage.

What are the storage conditions of Tretinoin?

Store at 15 to 30C. Keep the container tightly closed at room temperature and out of the reach of children.


Schedule : H

Prescription drugs - Drugs to be sold only under the prescription of a Registered Medical Practitioner.

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