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Tositumomab and Iodine 1131 Tositumomab

Latest prescription information about Tositumomab and Iodine 1131 Tositumomab. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Tositumomab and Iodine 1131 Tositumomab
Pronunciation : tos-IT-too-moe-mab
Therapeutic Classification : Radioactive Monoclonal Antibody
Trade Name(s): 
International- Bexxar.
Why it is prescribed (Indications) : 
This medication is a monoclonal antibody, prescribed for non-Hodgkin lymphoma. 
When it is not to be taken (Contraindications): 
Contraindicated to pregnant women.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
The recommended dose is 450 mg intravenously in 50 ml 0.9% Sodium Chloride over 60 minutes.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of infection, thyroid problems, recent vaccination, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
* Avoid live vaccination during the treatment period.
* Monitor complete blood cell counts, platelet counts, thyroid function tests, and kidney function tests regularly while taking this medication.
Side Effects : 
General- Weakness, fever, infection, pain, chills, headache, abdominal pain, back pain, chest pain, neck pain.
Heart - Low blood pressure, dilatation of blood vessels.
Gastrointestinal - Nausea, vomiting, loss of appetite, diarrhea, constipation, and indigestion.
Metabolic - Underactive thyroid, swelling in the extremities, weight loss.
Musculoskeletal - Muscle pain, joint pain.
Central Nervous System - Dizziness and drowsiness.
Respiratory - Increased cough, inflammation of pharynx, difficulty in breathing, pneumonia.
Skin - Rash, itching, increased sweating.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it in refrigerator (2°–8°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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