Information about Tositumomab

Generic Name : Tositumomab
Up-to-date prescription details regarding Tositumomab are provided here.

Pronunciation : tos-IT-too-moe-mab

Learn the correct pronunciation of the Tositumomab, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Therapeutic Classification : Radioactive Monoclonal Antibody

Trade Names/Brand Names of Tositumomab

International :

Bexxar

Why is Tositumomab Prescribed? (Indications)

This medication is a radioactive monoclonal antibody, prescribed for non-Hodgkin’s lymphoma in patients who have not responded to other therapy. It works by killing cancer cells.

When should Tositumomab not be taken? (Contraindications)

Contraindicated in pregnant women, and patients with known hypersensitivity.

What is the dosage of Tositumomab?

IV- The recommended dose is 5.0 mCi Iodine-131 and 35 mg Tositumomab in 30 ml 0.9% sodium chloride over 20 minutes.

How should Tositumomab be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Tositumomab?

• Caution should be exercised in patients with history of infection, thyroid problems, kidney impairment, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.

• Avoid vaccination during the treatment period.

• Patient may develop with increased risk of thyroid damage; consult with your doctor before taking this medication.

• It may reduce blood cells, which may increase the risk of bleeding or infection. Avoid bruising or injury and contact with people who have infections.

What are the side effects of Tositumomab?

Most Common - Decrease in blood cells.
Body as a Whole - Weakness, fever, infection, body pain, chills, headache, abdominal pain, back pain, chest pain, and neck pain.
Heart - Low blood pressure and dilatation of blood vessels.
Gastrointestinal - Nausea, vomiting, loss of appetite, diarrhea, constipation, and indigestion.
Endocrine - Decrease in thyroid hormone.
Metabolic - Swelling in the extremities, and weight loss.
Musculoskeletal - Joint pain and muscle pain.
Central Nervous System - Dizziness, and drowsiness.
Respiratory - Increased cough, difficulty in breathing, nose inflammation and lung infection.
Skin - Rash, itching, and increased sweating.