Tolterodine belongs to a class of medicines known as antimuscarinics. It is prescribed for the treatment of overactive bladder with symptoms of urinary incontinence, urgency and frequency. It acts by relaxing the bladder muscles. It has also been tried for the treatment of bedwetting caused by overactive bladder in children who are above the age of 5 years.
Tolterodine is contraindicated in patients who are allergic to the drug, with urinary retention, functional or structural gastrointestinal problems that reduce motility, increased eye pressure (glaucoma)and severe liver disease.
Adult- The recommended dose is 4 mg once daily or 2 mg twice daily orally.
It comes as a tablet or as an extended release capsule to be taken by mouth, with liquids.
Caution should be exercised in patients with history of kidney or liver disease, severe obstruction of stomach/intestine such as pyloric narrowing, enlarged prostate, heart problems, elderly, children, during pregnancy and breastfeeding.
Patients may be at increased risk of QT prolongation, an abnormality in the electrical activity of the heart; if it so consult with your doctor.
Avoid driving a car or operating machinery while taking this medication as it may cause dizziness or drowsiness.
Avoid alcohol consumption as it may worsen the side effects of the drug.
General: Headache, dry mouth, fatigue, rash and severe allergic reactions.
Central Nervous System: Dizziness, confusion, disorientation, memory loss, hallucinations, drowsiness and anxiety.
Heart: Fast heart rate, chest pain and fluid accumulation.
Gastrointestinal: Constipation, abdominal pain, and indigestion.
Eye: Dry eyes and blurred vision.
Respiratory: Inflammation of sinuses, bronchi and other parts of the respiratory tracts.
Genitourinary: Painful urination.
Avoid exposure to sunlight while on the drug since it inhibits sweating and heatstroke may occur.
Tolterodine should be avoided with:
Anti-arrhythmic drugs like amiodarone and quinidine which are used in the treatment of arrhythmias (abnormal heart rhythms) as it would result in increased chances of abnormal heartbeat.
Antibiotics like erythromycin and clarithromycin, azole antifungals like itraconazole and ketoconazole, the antiviral drug ritonavir, antidepressant fluoxetine and anticholinergics like scopolamine and atropine, since they could increase the side effects of the drug.
Store the drug in a tightly closed container at room temperature. Keep away from excess heat and moisture. Keep out of reach of children.
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