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Tolcapone

Latest prescription information about Tolcapone. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Tolcapone
Pronunciation : TOLE-ka-pone
Trade Name(s): 
International- Tasmar.
Why it is prescribed (Indications) : 
This medication is a catechol-O-methyl transferase (COMT) inhibitor, prescribed for Parkinson's disease along with levodopa/carbidopa.

When it is not to be taken (Contraindications): 


Contraindicated in patients with rhabdomyolysis (condition in which skeletal muscle cells break down), liver disease and hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Initial: The recommended dose is 100 mg, three times per day.
How it should be taken : 
It comes as a tablet to take by mouth, as directed by your physician.
Special Instruction : 
* Caution should be exercised in patients with history of heart or kidney disease, elderly, during pregnancy and breastfeeding.
* It may cause dizziness or drowsiness, do not drive a car or operate machinery while taking this medication.
* Avoid alcohol consumption.
Side Effects : 
Most Common- Movement disorder, nausea, sleep disorder, involuntary movements, excessive dreaming, loss of appetite, muscular cramps, orthostatic complaints, drowsiness, diarrhea, confusion, dizziness, headache, hallucinations, vomiting, constipation, fatigue, upper respiratory tract infection, falling, increased sweating, urinary tract infection, dry mouth, abdominal pain and urine discoloration.
Central Nervous System- Depression, sensory loss, tremor, speech disorder, unsteadiness and emotional lability.
Gastrointestinal- Tooth disorder.
Body as a Whole- Flank pain, accidental injury, abdominal pain and infection.
Heart- Palpitations.
Musculoskeletal- Muscle pain.
Genitourinary- Urinary incontinence and impotence.
Respiratory- Inflammation of bronchus and pharynx.
Eye and ENT- Ringing in the ear.
Other Precautions : 
*Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (20° to 25°C).

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