Tizanidine - Drug Information

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General Information on Tizanidine

Generic Name : Tizanidine

Pronunciation : tye-ZAN-i-deen

Latest prescription information about Tizanidine. Learn how to pronounce the drug's name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
ICD Code : Y55.1 | Therapeutic Classification : Skeletal Muscle Relaxants

Why is Tizanidine Prescribed? (Indications)

This medication is a centrally acting muscle relaxant. It is used to treat the spasticity especially due to neurological disorders, and in painful muscle spasms of spinal origin. It blocks nerves that stimulate muscles to contract.

When should Tizanidine not to be taken? (Contraindications)

Hypersensitivity.

Pregnancy Category

A B C D X

Category C :

Animal studies have shown adverse effects on the fetus and there are no appropriate studies in pregnant women, but potential benefits may allow the use of the drug in pregnant women despite the potential for risks.

What is the dosage of Tizanidine?

Adult: Spasticity-PO- The initial recommended dose is 2 mg once daily for, increase slowly if needed, up to 24 mg/day in 3-4 divided doses. Max: 24 mg/day; 8 mg/dose.
Painful muscle spasm associated with musculoskeletal conditions: 2-4 mg 3 times/day.

How should Tizanidine be taken?

It comes as a tablet as well as capsule, to take by mouth with or without food, twice or thrice a day.

What are the warnings and precautions for Tizanidine?

Caution should be exercised in patients with history of prolonged QT interval, liver or kidney disease, children, elderly, pregnancy and breastfeeding.
Monitor LFT(Liver Function test) regularly.
Stop treatment if liver enzymes are raised persistently greater than 3 times upper limit of normal range.
Avoid abrupt withdrawal of therapy.
It may make you drowsy. Do not drive a car or operate machinery while taking this medication.

What are the side effects of Tizanidine?

  Most Common: Dry mouth, increased spasm or tone of muscles, and dizziness.
  Heart: Dilatation of blood vessels, postural hypotension, abnormal heart rhythm.
  Gastrointestinal: Abdomen pain, diarrhea, blood in stool, difficulty in swallowing, nausea, loss of appetite.
  Liver: Increase in liver enzymes, liver damage.
  Blood: Unusual bleeding, high blood cholesterol, anemia, decrease in white blood cells, systemic inflammatory response syndrome.
  Metabolic : Swelling of leg, hypothyroidism, weight loss.
  Musculoskeletal: Autoimmune neuromuscular disease, back pain.
  Central Nervous System: Sedation, depression, anxiety, tingling, hallucinations.
  Respiratory : Sinusitis, pneumonia, inflammation of bronchus.
  Skin : Rash, sweating, skin ulcer, itching, dry skin, acne, hair loss, hives.
  Eye and ENT: Ear pain, tinnitus, deafness, glaucoma, conjunctivitis, eye pain, optic nerve disease, inflammation of middle ear, eye bleeding, visual field defect.
  Genitourinary: Urinary urgency, heavy menstrual bleeding, urinary tract infection, urinary retention, kidney stone, increase in size of uterine fibroids, vaginal yeast infections, inflammation of vagina.

What are the other precautions for Tizanidine?


It may cause dizziness, lightheadedness, and fainting when you get up too quickly from a lying position. Get up slowly from bed.

What are the storage conditions of Tizanidine?

Store it in an airtight container. Store it at room temperature and keep away from children, excess heat and moisture.

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