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Tirofiban Hcl

Latest prescription information about Tirofiban Hcl. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Tirofiban Hcl
Pronunciation : tye-roe-FYE-ban
Therapeutic Classification : Anticoagulants / Antithrombotics
ICD Code : Y44.2
Trade Name(s): 
India- Aggramed, Aggrastat, Aggribloc, Aggritor, Agraban, GP-2 Ban, Tiroban, Tirofuse, Xtrabaniv.
International- Aggrastat.
Why it is prescribed (Indications) : 
This medication is a platelet aggregation inhibitor, prescribed for the management of patients with unstable angina or non-Q-wave myocardial infarction, including patients who may subsequently undergo percutaneous transluminal coronary angioplasty (PTCA) with other medications. 
When it is not to be taken (Contraindications): 
Contraindicated in patients with active internal bleeding, stroke, brain tumor, aneurysm, trauma, high blood pressure, and hypersensitivity.

Pregnancy Category :

A B C D X
Category B : Animal reproduction studies have failed to demonstrate a risk to the fetus and there are no adequate and well-controlled studies in pregnant women OR Animal studies have shown an adverse effect, but adequate and well-controlled studies in pregnant women have failed to demonstrate a risk to the fetus in any trimester.

Dosage & When it is to be taken : 
Adult: IV- Non-ST-segment elevation MI; Unstable angina- Loading dose: 0.4 mcg/kg/min for 30 mins, then 0.1 mcg/kg/min for ≥24-48 hours.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* Caution should be exercised in patients with history of decreased blood platelets, high blood volume, kidney impairment, bleeding problems in the eye, any allergy, who are taking other medications, elderly, children, during pregnancy and breastfeeding.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts; avoid injury or bruising to prevent bleeding.
* Monitor complete blood counts regularly while taking this medication.
Side Effects : 
Most Common - Major bleeding.
Body as a Whole - Fever and chills.
Central Nervous System - Dizziness.
Skin - Sweating.
Musculoskeletal - Leg pain.
Heart - Slow heart beat.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at room temperature (25°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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