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Thrombin Topical Bovine Origin

Latest prescription information about Thrombin Topical Bovine Origin. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Thrombin Topical Bovine Origin
Pronunciation : THROM-bin
Therapeutic Classification : Hematologic Agents
Trade Name(s): 
International- Thrombin- JMI, Recothrom, Thrombi-Gel 10, Thrombi-Gel 40, Thrombi-Gel 100, Thrombi-Pad 3×3.
Why it is prescribed (Indications) : 
This medication is hematologic agent, prescribed for hemostasis and for temporary control of moderately to severely bleeding wounds.  
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Topical- The recommended concentration of 1,000 to 2,000 International Units/mL is required.
How it should be taken : 
It comes as a solution for topical use; apply as directed by your physician.
Warnings and Precautions : 
* Caution should be exercised in patients with history of infection, any allergy, elderly, children, during pregnancy and breastfeeding.
* For external use only.
* Patient may develop with increased risk of infections such as Creutzfeldt-Jakob disease; if it is so consult with your healthcare provider.
Side Effects : 
Most Common - Allergic reactions.
Heart - Blood clots.
Gastrointestinal - Nausea and vomiting.
Lab Tests - Increased APTT, prolonged PT, decreased lymphocytes, increased neutrophils.
Miscellaneous - Incision-site complication, injection site pain, infection, bleeding, postoperative wound infection, itching, and antibody formation.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at 2°–25°C.


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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