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Thiotepa

Latest prescription information about Thiotepa. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Thiotepa
Pronunciation : (thye oh tep' a)
Therapeutic Classification : Chemotherapy
Trade Name(s): 
International- Thioplex.
Why it is prescribed (Indications) : 
This medication is a chemotherapy agent, prescribed for ovary or breast cancer.

When it is not to be taken (Contraindications): 


Contraindicated in patients with liver, kidney disease, bone marrow depression and hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.


When it is to be taken : 
Breast and Ovarian Carcinoma: Adults- IV- 0.3 to 0.4 mg/kg every 1 to 4 week. Alternative regimens- 0.2 mg/kg/day for 4 to 5 days every 2 to 4 week; or 6 mg/m 2 /day for 4 to 5 days every 2 to 4 week.
How it should be taken : 
It comes as a solution for injection to be administered by a healthcare provider into the vein.
Special Instruction : 
* Caution should be exercised in patients with history of kidney or liver problems, bone marrow problems, agranulocytosis, any allergy, who are taking other medications, during pregnancy and breastfeeding.
* It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.
* It may reduce platelet counts, avoid injury or bruising.
* Avoid live vaccination.
Side Effects : 
General - Fatigue and weakness.
Hypersensitivity - Allergic reactions - rash, hives, laryngeal edema, asthma, shock and wheezing.
Local - Skin inflammation and pain at the injection site.
Gastrointestinal - Nausea, vomiting, abdominal pain and loss of appetite.
Genitourinary - Painful urination and urinary retention.
Respiratory - Difficulty in breathing.
Central Nervous System - Dizziness, headache and blurred vision.
Skin - Hair loss.
Eye - Eye inflammation.
Genitourinary - Absence of menstrual periods and decrease in sperm count.
Other Precautions : 
* Monitor liver function, kidney function, and white blood cell counts regularly while taking this medication.
Storage Conditions : 
Store it at 8°C and in the container it came in.

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