Information about Thiotepa

Generic Name : Thiotepa
Up-to-date prescription details regarding Thiotepa are provided here.

Pronunciation : (thye oh tep' a)

Learn the correct pronunciation of the Thiotepa, understand it's uses, recommended dosages, its indications, how to take, when to take, when not to take, side effects, special precautions, warnings and its and its storage instructions.

You will also find a list of the medication's International and Indian brand or trade names, as well as its pricing information. For verification of the information presented on this page or for additional clarifications, it's advisable to consult your doctor.

Trade Names/Brand Names of Thiotepa

Tespamin

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International :

Thioplex

Why is Thiotepa Prescribed? (Indications)

This medication is a chemotherapy agent, prescribed for ovary or breast cancer. It works by killing cancer cells.

When should Thiotepa not be taken? (Contraindications)

Contraindicated in patients with liver, kidney disease, bone marrow depression and hypersensitivity.

What is the dosage of Thiotepa?

Breast and Ovarian Carcinoma: Adults- IV- 0.3 to 0.4 mg/kg every 1 to 4 week. Alternative regimens- 0.2 mg/kg/day for 4 to 5 days every 2 to 4 week; or 6 mg/m 2 /day for 4 to 5 days every 2 to 4 week.

How should Thiotepa be taken?

It comes as a solution for injection to be administered by a healthcare provider into the vein.

What are the warnings and precautions for Thiotepa?

• Caution should be exercised in patients with history of kidney or liver problems, bone marrow problems, agranulocytosis, any allergy, who are taking other medications, during pregnancy and breastfeeding.

• It may cause dizziness or blurred vision, do not drive a car or operate machinery while taking this medication.

• It may reduce platelet counts, avoid injury or bruising.

• Avoid live vaccination.

What are the side effects of Thiotepa?

General - Fatigue and weakness.
Hypersensitivity - Allergic reactions - rash, hives, laryngeal edema, asthma, shock and wheezing.
Local - Skin inflammation and pain at the injection site.
Gastrointestinal - Nausea, vomiting, abdominal pain and loss of appetite.
Genitourinary - Painful urination and urinary retention.
Respiratory - Difficulty in breathing.
Central Nervous System - Dizziness, headache and blurred vision.
Skin - Hair loss.
Eye - Eye inflammation.
Genitourinary - Absence of menstrual periods and decrease in sperm count.