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Teniposide

Latest prescription information about Teniposide. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Teniposide
Pronunciation : ten-i-POE-side
Therapeutic Classification : Chemotherapy
Trade Name(s): 
International- Vumon.
Why it is prescribed (Indications) : 
This medication is an antineoplastic agent, prescribed for leukemia in combination with other medications. It slows or stops the growth of cancer cells in the body.
When it is not to be taken (Contraindications): Hypersensitivity.

Pregnancy Category :

A B C D X
Category D : There is positive evidence of human fetal risk based on adverse reaction data from investigational or marketing experience or studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
IV- The recommended dose is Teniposide 165 mg/m2 and cytarabine 300 mg/m 2 twice weekly for 8 to 9 doses.
How it should be taken : 
It comes as a solution for injection, to be administered by a healthcare provider into the vein.
Warnings and Precautions : 
* It may cause drowsiness, dizziness, or blurred vision, do not drive a car or operate machinery while taking this medication.
* Do not receive any vaccination while taking this medication.
* Monitor complete blood count, kidney and liver functions regularly.
* It may reduce the platelet counts in blood, avoid unusual bruising or bleeding.
* It may reduce the number of white blood cells and lead to infections.
* Caution should be exercised in patients with history of Down syndrome, alcoholism, elderly patients, during pregnancy and breastfeeding.
* It may result in hair loss.
Side Effects : 
Heart - Low blood pressure.
Skin - Hair loss and rash.
Gastrointestinal - Painful ulceration, diarrhea and nausea/vomiting.
Blood - Anemia, decrease in white blood cells and platelets, and bleeding.
Hypersensitivity - Hypersensitivity reactions such as asthma, chills, difficulty in breathing, fever, flushing, high blood pressure and fast heart rate.
Miscellaneous - Infection and fever.
Other Precautions : 
* It should not be used in infants and newborns.
Storage Conditions : 
Store the unopened ampules under refrigeration (2°-8°C).

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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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