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Sulfisoxazole

Latest prescription information about Sulfisoxazole. Learn how to pronounce the drug’s name, its indications, dosage, how to take, when to take, when not to take, side effects, special precautions, its storage instructions and warnings if any when taken during pregnancy. Also listed are the International and Indian trade name(s) of the drug and its price list.
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Generic Name : Sulfisoxazole
Pronunciation : sul fi sox' a zole
Therapeutic Classification : Anti- Infectives
ICD Code : Y41.8
Trade Name(s): 
International- Sulfafurazole, Gantrisin.
Why it is prescribed (Indications) : 
This medication is a sulfonamide antibacterial, prescribed for treating and preventing certain bacterial infections. It helps keep bacteria from growing in the body.
When it is not to be taken (Contraindications): Contraindicated in patients with severe kidney disease, anemia, hypersensitivity, during pregnancy and breastfeeding.

Pregnancy Category :

A B C D X
Category C : Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

Dosage & When it is to be taken : 
Initial dose: One half of the 24-hour dose. Maintenance dose: 150 mg/kg/24 hours or 4 gm/M²/24 hours - dose to be divided into 4 to 6 doses/24 hours.
How it should be taken : 
It comes as a tablet and liquid to take by mouth, with or without food.
Warnings and Precautions : 
* Caution should be exercised in patients with history of diarrhea, sore throat, stomach or intestinal infection, asthma, glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, blood problems, liver or kidney problems, any allergy, who are taking other medications.
* It may cause dizziness, do not drive a car or operate machinery while taking this medication.
* Avoid long-term use of this medication; otherwise it may cause secondary infection.
* Avoid exposure to sunlight.
* It should not be used in children less than 2 years old.
Side Effects : 
Allergic Reactions - Shock, serum sickness, rash, hives, itching and sensitivity to light.
Heart - Fast heart rate, palpitations, fainting and bluish.
Gastrointestinal - Liver inflammation, jaundice, nausea, vomiting, loss of appetite, abdominal pain, diarrhea, gastrointestinal bleeding, blood in stools, flatulence, mouth ulcer, salivary gland enlargement and inflammation of pancreas/tongue.
Genitourinary - Blood in urine, BUN and creatinine elevations, kidney inflammation and urinary retention.
Blood - Decrease in white blood cells, platelets, bruising, anemia, eosinophilia and clotting disorders.
Musculoskeletal - Muscle/joint pain.
Central Nervous System - Headache, dizziness, tingling, convulsions, ringing in the ear, unsteadiness, incoordination, stroke, mental depression, hallucinations, disorientation, depression, anxiety and apathy.
Respiratory - Cough, shortness of breath and pulmonary infiltrates.
Miscellaneous - Swelling in the extremities, fever, drowsiness, weakness, fatigue, lack of energy, rigors, flushing, hearing loss, sleeplessness, lung inflammation and chills.
Other Precautions : 
* Avoid excess dosage.
Storage Conditions : 
Store it at controlled room temperature (15 to 30°C).


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Reference  

  • Food and Drug Administration (FDA)
  • National Institutes of Health (NIH)
  • PubMed
  • CIMS
  • Indian Pharma Reference Guide 2012
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